@article{ART003390672},
author={황효인 and 전용현 and 박정희 and 신혜경 and 정윤영 and 김동준},
title={Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2026},
volume={39},
number={3},
pages={251-258},
doi={10.11637/aba.2026.39.3.251}
TY - JOUR
AU - 황효인
AU - 전용현
AU - 박정희
AU - 신혜경
AU - 정윤영
AU - 김동준
TI - Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion
JO - Anatomy & Biological Anthropology
PY - 2026
VL - 39
IS - 3
PB - 대한체질인류학회
SP - 251
EP - 258
SN - 2671-5651
AB - Background
Oxidative stress and altered intracellular signaling contribute to ischemic brain injury. However, changes in antioxidant and neuroprotective signaling molecules during the subacute phase after permanent cerebral ischemia remain incompletely understood.
Methods
Male mice underwent permanent MCAO using the intraluminal filament method. Cortical tissue was collected 3 days after ischemia. Western blot analysis was performed for NRF2, HO-1, BDNF, phosphorylated AKT, and phosphorylated ERK.
Results
NRF2 and HO-1 expression significantly decreased in the MCAO group. BDNF expression significantly increased following ischemia. The pAKT/AKT ratio was significantly reduced, whereas the pERK/ERK ratio showed no significant difference.
Conclusion
Permanent cerebral ischemia induces suppression of antioxidant defense and AKT signaling while increasing BDNF expression, suggesting simultaneous activation of compensatory neuroprotective mechanisms during the subacute stage.
KW - MCAO;NRF;HO-1;BDNF;AKT
DO - 10.11637/aba.2026.39.3.251
ER -
황효인, 전용현, 박정희, 신혜경, 정윤영 and 김동준. (2026). Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion. Anatomy & Biological Anthropology, 39(3), 251-258.
황효인, 전용현, 박정희, 신혜경, 정윤영 and 김동준. 2026, "Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion", Anatomy & Biological Anthropology, vol.39, no.3 pp.251-258. Available from: doi:10.11637/aba.2026.39.3.251
황효인, 전용현, 박정희, 신혜경, 정윤영, 김동준 "Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion" Anatomy & Biological Anthropology 39.3 pp.251-258 (2026) : 251.
황효인, 전용현, 박정희, 신혜경, 정윤영, 김동준. Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion. 2026; 39(3), 251-258. Available from: doi:10.11637/aba.2026.39.3.251
황효인, 전용현, 박정희, 신혜경, 정윤영 and 김동준. "Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion" Anatomy & Biological Anthropology 39, no.3 (2026) : 251-258.doi: 10.11637/aba.2026.39.3.251
황효인; 전용현; 박정희; 신혜경; 정윤영; 김동준. Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion. Anatomy & Biological Anthropology, 39(3), 251-258. doi: 10.11637/aba.2026.39.3.251
황효인; 전용현; 박정희; 신혜경; 정윤영; 김동준. Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion. Anatomy & Biological Anthropology. 2026; 39(3) 251-258. doi: 10.11637/aba.2026.39.3.251
황효인, 전용현, 박정희, 신혜경, 정윤영, 김동준. Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion. 2026; 39(3), 251-258. Available from: doi:10.11637/aba.2026.39.3.251
황효인, 전용현, 박정희, 신혜경, 정윤영 and 김동준. "Expression Changes of Neuroprotective Signaling Molecules in the Mouse Cortex Following Permanent Middle Cerebral Artery Occlusion" Anatomy & Biological Anthropology 39, no.3 (2026) : 251-258.doi: 10.11637/aba.2026.39.3.251
