@article{ART003390674},
author={김윤경 and Kim Yun Sook},
title={Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2026},
volume={39},
number={3},
pages={259-268},
doi={10.11637/aba.2026.39.3.259}
TY - JOUR
AU - 김윤경
AU - Kim Yun Sook
TI - Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp
JO - Anatomy & Biological Anthropology
PY - 2026
VL - 39
IS - 3
PB - 대한체질인류학회
SP - 259
EP - 268
SN - 2671-5651
AB - Voltage-gated sodium channel 1.8 (Nav1.8) is important for the generation and propagation of action potentials in primary nociceptors. Nav1.8 is also involved in acute pain and inflammation-induced pain hypersensitivity. However, it remains unclear whether Nav1.8-mediated nociceptive input is associated with distinct vesicular glutamate transporters (VGLUTs). To investigate this, we examined the coexpression of Nav1.8 with VGLUT1 or VGLUT2 in the rat trigeminal ganglion (TG) and tooth pulp using fluorescence immunohistochemistry.
Most Nav1.8-immunopositive (Nav1.8+) neurons in the TG and Nav1.8+ nerve fibers in the tooth pulp coexpressed VGLUT2, whereas coexpression with VGLUT1 was very rare. In addition, Nav1.8+ neurons in the TG coexpressed substance P, calcitonin gene-related peptide, or isolectin B4, which are markers of nociceptive neurons, but rarely coexpressed parvalbumin or neurofilament 200, which are expressed in relatively large-diameter sensory neurons.
Our findings suggest that Nav1.8 is mostly expressed in nociceptive neurons in the TG and nerve fibers in the tooth pulp and is preferentially associated with VGLUT2 rather than VGLUT1. The selective coexpression of Nav1.8 and VGLUT2 suggests that Nav1.8+ nociceptors may contribute to nociceptive transmission through VGLUT2-dependent glutamatergic neurotransmission.
KW - Nav1.8;VGLUT1;VGLUT2;tooth pulp
DO - 10.11637/aba.2026.39.3.259
ER -
김윤경 and Kim Yun Sook. (2026). Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp. Anatomy & Biological Anthropology, 39(3), 259-268.
김윤경 and Kim Yun Sook. 2026, "Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp", Anatomy & Biological Anthropology, vol.39, no.3 pp.259-268. Available from: doi:10.11637/aba.2026.39.3.259
김윤경, Kim Yun Sook "Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp" Anatomy & Biological Anthropology 39.3 pp.259-268 (2026) : 259.
김윤경, Kim Yun Sook. Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp. 2026; 39(3), 259-268. Available from: doi:10.11637/aba.2026.39.3.259
김윤경 and Kim Yun Sook. "Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp" Anatomy & Biological Anthropology 39, no.3 (2026) : 259-268.doi: 10.11637/aba.2026.39.3.259
김윤경; Kim Yun Sook. Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp. Anatomy & Biological Anthropology, 39(3), 259-268. doi: 10.11637/aba.2026.39.3.259
김윤경; Kim Yun Sook. Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp. Anatomy & Biological Anthropology. 2026; 39(3) 259-268. doi: 10.11637/aba.2026.39.3.259
김윤경, Kim Yun Sook. Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp. 2026; 39(3), 259-268. Available from: doi:10.11637/aba.2026.39.3.259
김윤경 and Kim Yun Sook. "Coexpression of Nav1.8 and VGLUTs in the Rat Trigeminal Ganglion and Tooth Pulp" Anatomy & Biological Anthropology 39, no.3 (2026) : 259-268.doi: 10.11637/aba.2026.39.3.259
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