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Sensitive and selective electrochemical detection of acetaminophen based on GO-MnO2-modified electrode

  • Carbon Letters
  • Abbr : Carbon Lett.
  • 2025, 35(1), pp.245~255
  • DOI : 10.1007/s42823-024-00787-1
  • Publisher : Korean Carbon Society
  • Research Area : Natural Science > Natural Science General > Other Natural Sciences General
  • Received : April 27, 2024
  • Accepted : August 6, 2024
  • Published : March 28, 2025

K. Suresh 1

1Bharathiar University

Accredited

ABSTRACT

This article describes an efficient electrochemical sensor based on a graphene oxide- manganese dioxide (GO-MnO2) nanocomposite for detecting acetaminophen (AAP) in human fluids. The MnO2-wrapped GO sensing element was prepared by a simple and environmentally friendly co-precipitation method. The prepared GO-MnO2 nanostructure was characterized for its structural, morphological, and functional properties and tested for AAP detection. At a pH of 3, the electrochemical results revealed a high redox process toward AAP due to the transfer of two electrons and protons between the GO-MnO2/glassy carbon electrode (GO-MnO2/GCE) and AAP. The differential pulse voltammetry (DPV) analytical results showed the precise sensing ability of AAP in a wide linear range [0.125–2000 µM] with superior anti-interference ability. The calculated sensitivity of the GO-MnO2/GCE was 17.04 µAµM−1 cm−2, and the detection limit (LOD) was 7.042 nM. The sensor exhibited high reliability, good reproducibility, and a good recovery range of 98.47–99.22% in human urine sample analysis.

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