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Optimization of the whole extract of Zarawand Mudaharaj (Aristolochia rotunda L.) root by Response Surface Methodology (RSM)

  • CELLMED
  • Abbr : CellMed
  • 2021, 11(3), pp.15-15
  • DOI : 10.5667/CellMed.2021.0015
  • Publisher : Cellmed Orthocellular Medicine and Pharmaceutical Association
  • Research Area : Medicine and Pharmacy > General Medicine
  • Received : June 5, 2021
  • Accepted : August 25, 2021
  • Published : August 31, 2021

MD Zakir Ansari 1 Ghulamuddin Sofi 2 Hamiduddin 3 Haqeeq Ahmad 4 Rabia Basri 5 Abrar Alam 6

1Dept. of Ilmul Saidla (Unani Pharmacy), Sufia Unani Medical College Hoapital & Research Centre
2Department of Ilmul Advia, National Institute of Unani medicine
3Dept. of Ilmul Saidla (Unani Pharmacy), National Institute of Unani Medicine
4Dept. of Ilmul Advia (Pharmacology), National Institute of Unani Medicine
5Dept. of Amraz-e-Niswan wa Ilmul Qabalat (Gynae and Obstetrics), National Institute of Unani Medicine
6Department of Ilmul Advia (Pharmacology), Sufia Unani Medical College Hospital & Research Centre

Accredited

ABSTRACT

The chemical constitution of a drug has been accepted as an important basis for pharmacological action in Unani medicine. Various dosage forms have been developed on this concept, such as decoctions (Joshanda), infusions (Khesanda), extract (Rub / Usara), and syrup. Zarawand Mudaharaj (ZM.) / Aristolochia rotunda L. root was subjected to extraction process using Soxhlet’s apparatus by using Response Surface Methodology (RSM) to design the number of random runs of the extracts with variation in the factors of temperature, the concentration of ethanol in water, time for extraction, for optimizing and maximizing the yield concentration. The data obtained, was analyzed with regression equation and ANOVA two-way summary to interpret the interaction of the factors for yield maximization. Minitab version 18 was used to design and analyze data. Validation of the optimum conditions for maximum yield of the whole extract of ZM. Root was carried out by re-run of the extract using the optimized conditions. The maximum yield percentage thus obtained using RSM was 20.87% whereas using these optimum conditions 21.35 % yield was obtained thereby validating the method. The association between the response functions and the process variables was identified by a three-factor recorded Box-Behnken design. In the present study RSM is used because itis a cheap and affordable method to optimize maximum yield percentage which may be reliably used by researchers. The study set in the surface conditions for ZM. root extraction by the Soxhlet apparatus for maximizing the yield percentage.

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