@article{ART002961728},
author={Jwariya Shamim and Athar Parvez Ansari and Pankaj Goswami and Seema Akbar and Huzaifa Ansari and Abdul Wadud and Pervaiz Ahmad Dar},
title={Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats},
journal={CELLMED},
issn={3022-6805},
year={2023},
volume={13},
number={6},
pages={5-5},
doi={10.5667/CellMed.2023.005}
TY - JOUR
AU - Jwariya Shamim
AU - Athar Parvez Ansari
AU - Pankaj Goswami
AU - Seema Akbar
AU - Huzaifa Ansari
AU - Abdul Wadud
AU - Pervaiz Ahmad Dar
TI - Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats
JO - CELLMED
PY - 2023
VL - 13
IS - 6
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 5
EP - 5
SN - 3022-6805
AB - Objectives:Cassia occidentalis L. is a weed belonging to the Caesalpiniaceae family. The root of this medicinal plant is used for the treatment of various ailments, including kidney diseases. The present study was aimed at evaluating the nephroprotective effects of HAE of the roots of Cassia occidentalis L. against gentamicin-induced renal toxicity in albino Wistar rats.
Methods:The renal toxicity was induced by subcutaneous administration of gentamicin at 100 mg/kg in the rats belonging to the disease control and treatment groups from the 4th to the 8th day. The rats in the treatment group received HAE of the roots of Cassia occidentalis L. at 67 mg/kg b. w. orally for 8 days, while no treatment was given to the rats in the disease control and plain control groups. At the end of the experiment, renal biomarkers viz; s. creatinine, b. urea, and s. uric acid, were investigated. The histopathological examination of the kidney specimens was also carried out.
Results:The results of the present study revealed that renal function biomarkers such as s. creatinine, b. urea, and s. uric acid were significantly reduced in the rats of the treatment group as compared to those of the disease control group. Moreover, the histoarchitecture reports of the treatment group’s kidney specimens showed significant improvements.
Conclusion:The results suggested that the HAE of Cassia occidentalis L. roots promisingly prevented kidney injury in gentamicin-induced nephrotoxic rats. This effect might be due to improved clearance of gentamicin from the renal tubule and decreased generation of reactive oxygen species (ROS).
KW - Kasondi;Cassia occidentalis;Gentamicin-induced nephrotoxicity;Nephroprotective;Unani medicine
DO - 10.5667/CellMed.2023.005
ER -
Jwariya Shamim, Athar Parvez Ansari, Pankaj Goswami, Seema Akbar, Huzaifa Ansari, Abdul Wadud and Pervaiz Ahmad Dar. (2023). Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats. CELLMED, 13(6), 5-5.
Jwariya Shamim, Athar Parvez Ansari, Pankaj Goswami, Seema Akbar, Huzaifa Ansari, Abdul Wadud and Pervaiz Ahmad Dar. 2023, "Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats", CELLMED, vol.13, no.6 pp.5-5. Available from: doi:10.5667/CellMed.2023.005
Jwariya Shamim, Athar Parvez Ansari, Pankaj Goswami, Seema Akbar, Huzaifa Ansari, Abdul Wadud, Pervaiz Ahmad Dar "Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats" CELLMED 13.6 pp.5-5 (2023) : 5.
Jwariya Shamim, Athar Parvez Ansari, Pankaj Goswami, Seema Akbar, Huzaifa Ansari, Abdul Wadud, Pervaiz Ahmad Dar. Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats. 2023; 13(6), 5-5. Available from: doi:10.5667/CellMed.2023.005
Jwariya Shamim, Athar Parvez Ansari, Pankaj Goswami, Seema Akbar, Huzaifa Ansari, Abdul Wadud and Pervaiz Ahmad Dar. "Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats" CELLMED 13, no.6 (2023) : 5-5.doi: 10.5667/CellMed.2023.005
Jwariya Shamim; Athar Parvez Ansari; Pankaj Goswami; Seema Akbar; Huzaifa Ansari; Abdul Wadud; Pervaiz Ahmad Dar. Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats. CELLMED, 13(6), 5-5. doi: 10.5667/CellMed.2023.005
Jwariya Shamim; Athar Parvez Ansari; Pankaj Goswami; Seema Akbar; Huzaifa Ansari; Abdul Wadud; Pervaiz Ahmad Dar. Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats. CELLMED. 2023; 13(6) 5-5. doi: 10.5667/CellMed.2023.005
Jwariya Shamim, Athar Parvez Ansari, Pankaj Goswami, Seema Akbar, Huzaifa Ansari, Abdul Wadud, Pervaiz Ahmad Dar. Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats. 2023; 13(6), 5-5. Available from: doi:10.5667/CellMed.2023.005
Jwariya Shamim, Athar Parvez Ansari, Pankaj Goswami, Seema Akbar, Huzaifa Ansari, Abdul Wadud and Pervaiz Ahmad Dar. "Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats" CELLMED 13, no.6 (2023) : 5-5.doi: 10.5667/CellMed.2023.005
