@article{ART003203954},
author={Bong-Keun Jang and Sung-Bae Lee and Hye-Yeon Kang and Sunyoung Park and Seong-Hoon Yun and Gunwoo Lee and Youngsun Kwon and Hee-Yeong Jeong and Sang-Eun Shin and Kang-Il Oh and Jun-Hwan Jeong and Jeonghyun Kim and Seon-Yong Jeong},
title={Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model},
journal={CELLMED},
issn={3022-6805},
year={2025},
volume={15},
number={6},
pages={20-28}
TY - JOUR
AU - Bong-Keun Jang
AU - Sung-Bae Lee
AU - Hye-Yeon Kang
AU - Sunyoung Park
AU - Seong-Hoon Yun
AU - Gunwoo Lee
AU - Youngsun Kwon
AU - Hee-Yeong Jeong
AU - Sang-Eun Shin
AU - Kang-Il Oh
AU - Jun-Hwan Jeong
AU - Jeonghyun Kim
AU - Seon-Yong Jeong
TI - Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model
JO - CELLMED
PY - 2025
VL - 15
IS - 6
PB - Cellmed Orthocellular Medicine and Pharmaceutical Association
SP - 20
EP - 28
SN - 3022-6805
AB - Objective: Obesity is a complex chronic disease linked to over 200 chronic diseases and has increased in prevalence worldwide to date. This absolutely requires drastic lifestyle changes including practice of exercise and intake of low-calorie diet. However, many pharmacotherapies, approved by FDA, have recently been developed to improve obesity. Especially glucagon-like peptide 1 (GLP-1), a gut hormone that reduces appetite and promotes insulin secretion, has recently attracted much attention as a promising anti-obesity target. We developed ‘NEXITOP’ consisting of several natural substances that have previously been proven to help with obesity and aimed to evaluate the anti-obesity effects via GLP-1 modulation in high-fat diet (HFD)-induced obese mice.
Method: After early feeding HFD for 2 weeks, forty of C57BL/6J mice were divided into five groups: normal diet, HFD control, metformin (200 mg/kg), and NEXITOP (1300 or 2600 mg/kg). And then, NEXTOP and metformin were administered for 8 weeks.
Results: Feeding of HFD for 10 weeks dramatically increased both caloric intake and body weight (1.4 and 1.6-fold, respectively). While the administration of NEXITOP significantly improved both elevated caloric intake (19%) and body weight (12%). The administration of NEXITOP also showed reducible effects of abdominal fats (visceral; 2.1-fold, epididymal; 4.8-fold, retroperitoneal; 1.5-fold) in HFD-fed mice. Also, the administration of NEXITOP greatly elevated serum GLP-1 levels at 2, 4 and 6 weeks as well as its effects were superior to metformin at 2 and 4 weeks.
Conclusion: Our findings suggest that NEXITOP exerted an anti-obesity effect, and its underlying mechanism may involve regulation of the serum GLP-1 level.
KW - NEXTOP;glucagon-like peptide 1;body weight;calorie intake;fat
DO -
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Bong-Keun Jang, Sung-Bae Lee, Hye-Yeon Kang, Sunyoung Park, Seong-Hoon Yun, Gunwoo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Kang-Il Oh, Jun-Hwan Jeong, Jeonghyun Kim and Seon-Yong Jeong. (2025). Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model. CELLMED, 15(6), 20-28.
Bong-Keun Jang, Sung-Bae Lee, Hye-Yeon Kang, Sunyoung Park, Seong-Hoon Yun, Gunwoo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Kang-Il Oh, Jun-Hwan Jeong, Jeonghyun Kim and Seon-Yong Jeong. 2025, "Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model", CELLMED, vol.15, no.6 pp.20-28.
Bong-Keun Jang, Sung-Bae Lee, Hye-Yeon Kang, Sunyoung Park, Seong-Hoon Yun, Gunwoo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Kang-Il Oh, Jun-Hwan Jeong, Jeonghyun Kim, Seon-Yong Jeong "Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model" CELLMED 15.6 pp.20-28 (2025) : 20.
Bong-Keun Jang, Sung-Bae Lee, Hye-Yeon Kang, Sunyoung Park, Seong-Hoon Yun, Gunwoo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Kang-Il Oh, Jun-Hwan Jeong, Jeonghyun Kim, Seon-Yong Jeong. Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model. 2025; 15(6), 20-28.
Bong-Keun Jang, Sung-Bae Lee, Hye-Yeon Kang, Sunyoung Park, Seong-Hoon Yun, Gunwoo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Kang-Il Oh, Jun-Hwan Jeong, Jeonghyun Kim and Seon-Yong Jeong. "Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model" CELLMED 15, no.6 (2025) : 20-28.
Bong-Keun Jang; Sung-Bae Lee; Hye-Yeon Kang; Sunyoung Park; Seong-Hoon Yun; Gunwoo Lee; Youngsun Kwon; Hee-Yeong Jeong; Sang-Eun Shin; Kang-Il Oh; Jun-Hwan Jeong; Jeonghyun Kim; Seon-Yong Jeong. Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model. CELLMED, 15(6), 20-28.
Bong-Keun Jang; Sung-Bae Lee; Hye-Yeon Kang; Sunyoung Park; Seong-Hoon Yun; Gunwoo Lee; Youngsun Kwon; Hee-Yeong Jeong; Sang-Eun Shin; Kang-Il Oh; Jun-Hwan Jeong; Jeonghyun Kim; Seon-Yong Jeong. Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model. CELLMED. 2025; 15(6) 20-28.
Bong-Keun Jang, Sung-Bae Lee, Hye-Yeon Kang, Sunyoung Park, Seong-Hoon Yun, Gunwoo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Kang-Il Oh, Jun-Hwan Jeong, Jeonghyun Kim, Seon-Yong Jeong. Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model. 2025; 15(6), 20-28.
Bong-Keun Jang, Sung-Bae Lee, Hye-Yeon Kang, Sunyoung Park, Seong-Hoon Yun, Gunwoo Lee, Youngsun Kwon, Hee-Yeong Jeong, Sang-Eun Shin, Kang-Il Oh, Jun-Hwan Jeong, Jeonghyun Kim and Seon-Yong Jeong. "Anti-obesity effects of an herbal formula NEXITOP through upregulation of glucagon like peptide-1 production in a high fat diet-fed obese mouse model" CELLMED 15, no.6 (2025) : 20-28.
