PHILOSOPHY·THOUGHT·CULTURE 2023 KCI Impact Factor : 0.5
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pISSN : 1975-1621 / eISSN : 2092-0873
- https://journal.kci.go.kr/insewtdgu
KJCKorea
Journal Central
The self/nonself theory in immunology and antibody humanization
- PHILOSOPHY·THOUGHT·CULTURE
- 2021, (37), pp.126~146
- DOI : 10.33639/ptc.2021..37.006
- Publisher : Research Institute for East-West Thought
- Research Area : Humanities > Other Humanities
- Received : October 30, 2021
- Accepted : November 24, 2021
- Published : November 30, 2021
1전남대학교
Accredited
ABSTRACT
The philosophy of immunology tackles the problems of immunology. As immunology has many practical applications, the problem of immunology is closely related to our daily lives. Here, I inquire into the core theory of immunology: the discrimination between “self” and “nonself”. I also show that the concepts of humanness and humanization in the development of therapeutic antibodies are essentially an extended view of the self/nonself dichotomy.
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[book]
Abbas, A. K.
/ 2019
/ Basic immunology e-book : functions and disorders of the immune system
/ Elsevier Health Sciences
[journal]
Al-Quteimat, O. M.
/ 2020
/ The impact of the COVID-19 pandemic on cancer patients
/ American journal of clinical oncology
[journal]
Anderton, S. M.
/ 2002
/ Selection and fine-tuning of the autoimmune T-cell repertoire
/ Nature Reviews Immunology
[book]
Burnet, F. M.
/ 1949
/ The production of antibodies
/ Macmillan
[book]
Burnet, F. M.
/ 1940
/ Biological aspects of infectious disease
/ Macmillan
[book]
Burnet, F. M.
/ 1969
/ Cellular immunology: Self and Notself
/ Cambridge University Press
[book]
Burnet, F. M.
/ 1959
/ The clonal selection theory of acquired immunity
/ Cambridge University Press
[journal]
Choi, Y.
/ 2015
/ Antibody humanization by structure-based computational protein design
/ MAbs
[journal]
Gao, S. H.
/ 2013
/ Monoclonal antibody humanness score and its applications
/ BMC biotechnology
[journal]
He, L.
/ 2015
/ Hit-and-run, hit-and-stay, and commensal bacteria present different peptide content when viewed from the perspective of the T cell
/ Vaccine
[journal]
Hoogenboom, H. R.
/ 2005
/ Selecting and screening recombinant antibody libraries
/ Nature biotechnology
[journal]
Hwang, W. Y. K.
/ 2005
/ Immunogenicity of engineered antibodies
/ Methods
[book]
Janeway, C. A.
/ 1989
/ Cold Spring Harbor symposia on quantitative biology Vol.54
/ Cold Spring Harbor Laboratory Press
[journal]
Kiermer, V.
/ 2008
/ Antibodypedia
/ Nature Methods
[confproc]
Laayouni, H.
/ 2014
/ Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors
/ Proceedings of the National Academy of Sciences
[journal]
Lefranc, M. P.
/ 2009
/ IMGT®, the international ImMunoGeneTics information system
/ Nucleic acids research
[journal]
Marks, C.
/ 2021
/ Humanization of antibodies using a machine learning approach on large-scale repertoire data
/ Bioinformatics
[journal]
Marraffini, L. A.
/ 2008
/ CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA
/ Science
[journal]
Martín, R.
/ 2013
/ Role of commensal and probiotic bacteria in human health : a focus on inflammatory bowel disease
/ Microbial cell factories
[confproc]
Mazor, R.
/ 2014
/ Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
/ Proceedings of the National Academy of Sciences
[journal]
Meunier, S.
/ 2020
/ Impact of human sequences in variable domains of therapeutic antibodies on the location of CD4 T-cell epitopes
/ Cellular & molecular immunology
[journal]
Podust, V. N.
/ 2016
/ Extension of in vivo half-life of biologically active molecules by XTEN protein polymers
/ Journal of Controlled Release
[journal]
Pokhrel, S.
/ 2021
/ A literature review on impact of COVID-19 pandemic on teaching and learning
/ Higher Education for the Future
[book]
Pradeu, T.
/ 2020
/ Philosophy of immunology
/ Cambridge University Press
[journal]
Reichert, J. M.
/ 2005
/ Monoclonal antibody successes in the clinic
/ Nature biotechnology
[journal]
Richards, M.
/ 2020
/ The impact of the COVID-19 pandemic on cancer care
/ Nature Cancer
[journal]
Riechmann, L.
/ 1988
/ Reshaping human antibodies for therapy
/ Nature
[confproc]
Salvat, R. S.
/ 2017
/ Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity
/ Proceedings of the National Academy of Sciences
[journal]
Sarkodie, S. A.
/ 2021
/ Impact of COVID-19 pandemic on waste management
/ Environment, development and sustainability
[journal]
Sgro, C.
/ 1995
/ Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3 : bibliographic review
/ Toxicology
[journal]
Sharma, V. K.
/ 2016
/ A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes
/ Chemosphere
[journal]
Sher, L.
/ 2020
/ The impact of the COVID-19 pandemic on suicide rates
/ QJM: An International Journal of Medicine
[journal]
Silverstein, A. M.
/ 2000
/ Clemens Freiherr von Pirquet : explaining immune complex disease in 1906
/ Nature immunology
[journal]
Stebbins, C. E.
/ 2001
/ Structural mimicry in bacterial virulence
/ Nature
[journal]
Sutoh, Y.
/ 2021
/ The immune system of jawless vertebrates : insights into the prototype of the adaptive immune system
/ Immunogenetics
[journal]
Tangri, S.
/ 2005
/ Rationally engineered therapeutic proteins with reduced immunogenicity
/ The Journal of Immunology
[journal]
Turecek, P. L.
/ 2016
/ PEGylation of biopharmaceuticals : a review of chemistry and nonclinical safety information of approved drugs
/ Journal of pharmaceutical sciences
[journal]
Tuttle, K. R.
/ 2020
/ Impact of the COVID-19 pandemic on clinical research
/ Nature Reviews Nephrology
[journal]
Van Nhieu, G. T.
/ 1991
/ The Yersinia pseudotuberculosis invasin protein and human fibronectin bind to mutually exclusive sites on the alpha 5 beta 1 integrin receptor
/ Journal of Biological Chemistry
[journal]
Varki, A.
/ 2012
/ Multifarious roles of sialic acids in immunity
/ Annals of the New York Academy of Sciences
[journal]
Veronese, F. M.
/ 2001
/ Peptide and protein PEGylation : a review of problems and solutions
/ Biomaterials
[journal]
Wagner, K. S.
/ 2009
/ A review of the international issues surrounding the availability and demand for diphtheria antitoxin for therapeutic use
/ Vaccine
[journal]
Warmerdam, P. A. M.
/ 2002
/ Elimination of a human T-cell region in staphylokinase by T-cell screening and computer modeling
/ Thrombosis and haemostasis
[journal]
Xiong, J.
/ 2020
/ Impact of COVID-19 pandemic on mental health in the general population : A systematic review
/ Journal of affective disorders
[journal]
Yeung, V. P.
/ 2004
/ Elimination of an immunodominant CD4+ T cell epitope in human IFN-β does not result in an in vivo response directed at the subdominant epitope
/ The Journal of Immunology