Synthesis and bioactivity evaluation of metal ion-substitution biphasic calcium phosphate for bone defect reconstruction (골결손부 재건을 위한 금속 이온 치환 이상인산칼슘 합성 및 생체 활성 평가)

Taewan Kim (김태완); Kim Donghyun (김동현); 진형호; LEE SEUNG HO (이승호); PARK，HONG-CHAE (박홍채); Seog-Young Yoon (윤석영)

doi:10.6111/JKCGCT.2012.22.6.279

Synthesis and bioactivity evaluation of metal ion-substitution biphasic calcium phosphate for bone defect reconstruction

Journal of the Korean Crystal Growth and Crystal Technology
Abbr : J. Korean Cryst. Growth Cryst. Technol.
2012, 22(6), pp.279-285
DOI : 10.6111/JKCGCT.2012.22.6.279
Publisher : The Korea Association Of Crystal Growth, Inc.
Research Area : Engineering > Materials Science and Engineering

Taewan Kim ¹, Kim Donghyun ¹, 진형호 ¹, LEE SEUNG HO ², PARK，HONG-CHAE ¹, Seog-Young Yoon ¹

¹부산대학교
²한국세라믹기술원

Accredited

ABSTRACT

The co-precipitation technique has been applied to synthesize Biphasic Calcium Phosphate (BCP), Mg-BCP and Si-BCP. X-ray diffraction (XRD) and Fourier transformed infrared (FTIR) spectroscopy were used to characterize the structure of synthesized BCP, Mg-BCP and Si-BCP powders. The results have shown that BCP and substitution of magnesium and silicon in the calcium deficient apatites revealed the formation of biphasic mixtures of Hydroxyapatite (HAp)/β-Tricalcium phosphate (β-TCP) ratios after heating at 1000oC. Ionic substituted BCP is able to develop a new apatite phase on the surface in contact with physiological fluids faster than BCP does. An MTT assay indicated that BCP,Mg-BCP, and Si-BCP powders had no cytotoxic effects on MG-63 cells, and that they have good biocompatibility.

KEYWORDS

Biphasic calcium phosphate, Ionic-substituted, Magnesium, Silicon, Co-precipitation

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* References for papers published after 2023 are currently being built.

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Journal of the Korean Crystal Growth and Crystal Technology 2023 KCI Impact Factor : 0.19

Synthesis and bioactivity evaluation of metal ion-substitution biphasic calcium phosphate for bone defect reconstruction

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Journal of the Korean Crystal Growth and Crystal Technology 2023 KCI Impact Factor : 0.19

Synthesis and bioactivity evaluation of metal ion-substitution biphasic calcium phosphate for bone defect reconstruction

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