Synthesis and bioactivity evaluation of metal ion-substitution biphasic calcium phosphate for bone defect reconstruction (골결손부 재건을 위한 금속 이온 치환 이상인산칼슘 합성 및 생체 활성 평가)

Taewan Kim (김태완); Kim Donghyun (김동현); 진형호; LEE SEUNG HO (이승호); PARK,HONG-CHAE (박홍채); Seog-Young Yoon (윤석영)

doi:10.6111/JKCGCT.2012.22.6.279

Synthesis and bioactivity evaluation of metal ion-substitution biphasic calcium phosphate for bone defect reconstruction

Journal of the Korean Crystal Growth and Crystal Technology
Abbr : J. Korean Cryst. Growth Cryst. Technol.
2012, 22(6), pp.279~285
DOI : 10.6111/JKCGCT.2012.22.6.279
Publisher : The Korea Association Of Crystal Growth, Inc.
Research Area : Engineering > Materials Science and Engineering

Taewan Kim ¹, Kim Donghyun ¹, 진형호 ¹, LEE SEUNG HO ², PARK,HONG-CHAE ¹, Seog-Young Yoon ¹

¹부산대학교
²한국세라믹기술원

Accredited

ABSTRACT

The co-precipitation technique has been applied to synthesize Biphasic Calcium Phosphate (BCP), Mg-BCP and Si-BCP. X-ray diffraction (XRD) and Fourier transformed infrared (FTIR) spectroscopy were used to characterize the structure of synthesized BCP, Mg-BCP and Si-BCP powders. The results have shown that BCP and substitution of magnesium and silicon in the calcium deficient apatites revealed the formation of biphasic mixtures of Hydroxyapatite (HAp)/β-Tricalcium phosphate (β-TCP) ratios after heating at 1000oC. Ionic substituted BCP is able to develop a new apatite phase on the surface in contact with physiological fluids faster than BCP does. An MTT assay indicated that BCP,Mg-BCP, and Si-BCP powders had no cytotoxic effects on MG-63 cells, and that they have good biocompatibility.

KEYWORDS

Biphasic calcium phosphate, Ionic-substituted, Magnesium, Silicon, Co-precipitation

Journal Copyright Policy

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Citation status

* References for papers published after 2025 are currently being built.

[journal] K. de Groot / 1993 / Clinical applications of calcium phosphate biomaterials; A review / Ceram. Int 19 : 363~

[journal] M. Jarcho / 1986 / Biological aspects of calcium phosphates: properties and applications / Dent. Clin. North. Am 30 : 25~

[journal] R.W. Bucholz / 1987 / Hydroxyapatite and tricalcium phosphate bone graft substitutes / Orthop. Clin. North. Am 18 : 323~

[journal] L.L. Hench / 1998 / Bioceramics / J. Am. Ceram. Soc 81 : 1705~

[journal] C.P.A.T. Klein / 1983 / Biodegradation behavior of various cal-cium phosphate materials in bone tissue / J. Biomed. Mater. Res. A 17 : 769~

[journal] S.V. Dorozhkin / 2002 / Biological and medical significance of calcium phosphates / Angew. Chem. Int. Ed 41 : 3130~

[journal] S. Yamada / 1997 / Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/β-tricalcium phosphate ratios / Biomaterials 18 : 1037~

[journal] J.M. Bouler / 2000 / Biphasic calcium phosphates: Influence of three synthesis parameters on the HA/β-TCP ratio / J. Biomed. Mater. Res. A 51 : 680~

[journal] M. Jarcho / 1981 / Calcium phosphate ceramics as hard tissue prosthetic / Clin. Orthop. Relat. Res 157 : 259~

[journal] S.G. Dahl / 2001 / Incorporation and distribution of strontium in bone / Bone 28 : 446~

[journal] R.S. Lee / 2006 / Calcium phosphate microcrystal deposition in the human intervertebral disc / J. Anat 208 : 13~

[journal] N.C. Blumenthal / 1975 / Precipitation of calcium phosphates from electrolyte solutions III. Radiometric studies of the kinetics of precipitation and aging of calcium phosphates / Calcif. Tissue. Int 18 : 81~

[journal] A. Bigi / 1997 / Chemical and structural characterization of the mineral phase from cortical and trabecular bone / J. Inorg. Biochem 68 : 45~

[journal] R.Z. Le Geros / 1991 / Calcium phosphates in oral biology and medicine / Monogr. Oral. Sci 15 : 1~

[journal] I.R. Gibson / 1999 / Chemical characterization of silicon-substituted hydroxyapatite / J. Biomed. Mater. Res. A 44 : 422~

[journal] K.J. Lilley / 2005 / Cement from magnesium substituted hydroxyapatite / J. Mater. Sci. Mater. Med 16 : 455~

[journal] W.L. Suchanek / 2004 / Effect of sintered silicatesubstituted hydroxyapatite on remodelling processes at the bone-implant interface / Biomaterilas 25 : 4647~

[journal] J. Pena / 2003 / Hydroxyapatite, tricalcium phosphate and biphasic materials prepared by a liquid mix technique / J. Euro. Ceram. Soc 23 : 1687~

[journal] S.R. Kim / 2003 / Synthesis of Si, Mg substituted hydroxyapatites and their sintering behaviors / Biomaterials 24 : 1389~

[journal] O. Gauthier / 1998 / Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth / Biomaterials 19 : 133~

[book] R.Z. Le Geros / 1991 / Calcium phosphates in oral biology and medicine / Monographs in Oral Science Karger Basel : 31~

[journal] M. Palard / 2008 / Synthesis of silicated hydroxyapatite Ca10(PO4)6 − x(SiO4)x(OH)2 − x / J. Solid State Chem 181 : 1950~

[journal] Th. Leventouri / 2003 / Neutron powder diffraction studies of silicon-substituted hydroxyapatite / Biomaterials 24 : 4205~

[journal] A. Mortier / 1989 / Temperatureprogrammed characterization of synthetic calcium-deficient phosphate apatites / Thermochimica Act 143 : 265~

[journal] S. Gomes / 2010 / Thorough analysis of silicon substitution in biphasic calcium phosphate bioceramics: A multi-technique study / Acta Biomateralia 6 : 3264~

[journal] 김태완 / 2012 / Bioactivity behavior of Si and Mg ion-substituted biphasic calcium phosphate powders / 한국결정성장학회지 / 한국결정성장학회 22(2) : 92~98

[journal] S. Kannan / 2005 / Synthesis and characterization of magnesium substituted biphasic mixtures of controlled hydroxyapatite/ β-tricalcium phosphate ratios / J. Solid. State. Chem 178 : 3190~

[journal] L.H. Long / 2006 / Preparation of dense β-CaSiO3 ceramic with high mechanical strength and HAp formation ability in simulated body fluid / J. Eur. Ceram. Soc 26 : 1701~

[journal] C.W. Song / 2012 / In situ synthesis of silicon-substituted biphasic calcium phosphate and their performance in vitro / JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS / PERGAMON-ELSEVIER SCIENCE LTD 73(1) : 39~45

[journal] K.S. TenHuisen / 1997 / Effects of magnesium on the formation of calcium-deficient hydroxyapatite from CaHPO4 · 2H2O and Ca4(PO4)2O / J. Biomed. Mater. Res 36 : 306~

[journal] X. Lu / 2005 / Theoretical analysis of calcium phosphate precipitation in simulated body fluid / Biomaterials 26 : 1097~

[journal] 김태완 / 2012 / Bioactivity behavior of biphasic calcium phosphate powders prepared by co-precipitation method / 한국결정성장학회지 / 한국결정성장학회 22(2) : 92~104

KJCKorea
Journal Central

Journal of the Korean Crystal Growth and Crystal Technology 2025 KCI Impact Factor : 0.14 KCI-WoS Impact Factor : 0.45