@article{ART002177686},
author={Jinok Ham and Jisun Jang and IL WON KIM},
title={Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide},
journal={Journal of the Korean Crystal Growth and Crystal Technology},
issn={1225-1429},
year={2016},
volume={26},
number={6},
pages={232-237},
doi={10.6111/JKCGCT.2016.26.6.232}
TY - JOUR
AU - Jinok Ham
AU - Jisun Jang
AU - IL WON KIM
TI - Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide
JO - Journal of the Korean Crystal Growth and Crystal Technology
PY - 2016
VL - 26
IS - 6
PB - The Korea Association Of Crystal Growth, Inc.
SP - 232
EP - 237
SN - 1225-1429
AB - Cocrystallization of active pharmaceutical ingredients has been widely recognized as a versatile tool to regulate the physical properties of pharmaceutical compounds through designed crystal structures. Grinding or milling has been especially useful to screen the feasibility of cocrystal formation, and the addition of a small amount of liquid is routinely necessary. In the present study, the effect of temperature was studied for the milling cocrystallization of ibuprofen and nicotinamide to establish a liquid-free method. The milling-induced cocrystallization was more effective with liquid nitrogen cooling than at room temperature, which was confirmed by XRD and DSC analyses. This behavior was attributed to the limited molecular mobility below the glass transition temperatures of the cocrystal components, which made it effective to destruct the crystals of raw materials and consequently form the ibuprofen/nicotinamide cocrystal. Further studies would be necessary to establish the utility of the current conclusion to the field of pharmaceutical crystallization.
KW - Cocrystal;Ibuprofen;Nicotinamide;Liquid-free milling
DO - 10.6111/JKCGCT.2016.26.6.232
ER -
Jinok Ham, Jisun Jang and IL WON KIM. (2016). Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide. Journal of the Korean Crystal Growth and Crystal Technology, 26(6), 232-237.
Jinok Ham, Jisun Jang and IL WON KIM. 2016, "Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide", Journal of the Korean Crystal Growth and Crystal Technology, vol.26, no.6 pp.232-237. Available from: doi:10.6111/JKCGCT.2016.26.6.232
Jinok Ham, Jisun Jang, IL WON KIM "Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide" Journal of the Korean Crystal Growth and Crystal Technology 26.6 pp.232-237 (2016) : 232.
Jinok Ham, Jisun Jang, IL WON KIM. Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide. 2016; 26(6), 232-237. Available from: doi:10.6111/JKCGCT.2016.26.6.232
Jinok Ham, Jisun Jang and IL WON KIM. "Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide" Journal of the Korean Crystal Growth and Crystal Technology 26, no.6 (2016) : 232-237.doi: 10.6111/JKCGCT.2016.26.6.232
Jinok Ham; Jisun Jang; IL WON KIM. Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide. Journal of the Korean Crystal Growth and Crystal Technology, 26(6), 232-237. doi: 10.6111/JKCGCT.2016.26.6.232
Jinok Ham; Jisun Jang; IL WON KIM. Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide. Journal of the Korean Crystal Growth and Crystal Technology. 2016; 26(6) 232-237. doi: 10.6111/JKCGCT.2016.26.6.232
Jinok Ham, Jisun Jang, IL WON KIM. Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide. 2016; 26(6), 232-237. Available from: doi:10.6111/JKCGCT.2016.26.6.232
Jinok Ham, Jisun Jang and IL WON KIM. "Liquid-free milling to prepare a cocrystal of ibuprofen and nicotinamide" Journal of the Korean Crystal Growth and Crystal Technology 26, no.6 (2016) : 232-237.doi: 10.6111/JKCGCT.2016.26.6.232
