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Constructing Gene Regulatory Networks using Knock-out Data

  • Journal of The Korea Society of Computer and Information
  • Abbr : JKSCI
  • 2007, 12(6), pp.105-114
  • Publisher : The Korean Society Of Computer And Information
  • Research Area : Engineering > Computer Science

홍성룡 1 손기락 1

1한국외국어대학교

Accredited

ABSTRACT

A gene regulatory network is a network of genes representing how genes influence the activities of other genes. Nowadays from microarray experiments, a large number of measurements on the expression levels of genes are available. One of typical data is the so-called "steady-state model" data measuring the expression levels of other genes after knocking out a particular gene. This paper shows how to reverse engineer a parsimonious gene regulatory network, using these measurement data. Our model considers auto-regulation, which forms a cycle in a genetic network. We also model repressor and enhancer roles of genes, which are not considered in previous known methods.

Citation status

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