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@article{ART001495486},
author={임상섭 and Kyubum Wee},
title={Prediction of SNP interactions in complex diseases with mutual information and boolean algebra},
journal={Journal of The Korea Society of Computer and Information},
issn={1598-849X},
year={2010},
volume={15},
number={11},
pages={215-224}

TY - JOUR
AU - 임상섭
AU - Kyubum Wee
TI - Prediction of SNP interactions in complex diseases with mutual information and boolean algebra
JO - Journal of The Korea Society of Computer and Information
PY - 2010
VL - 15
IS - 11
PB - The Korean Society Of Computer And Information
SP - 215
EP - 224
SN - 1598-849X
AB - Most chronic diseases are complex diseases which are caused by interactions of several genes. Studies on finding SNPs and gene-gene interactions involved in the development of complex diseases can contribute to prevention and treatment of the diseases. Previous studies mostly concentrate on finding only the set of SNPs involved. In this study we suggest a way to see how these SNPs interact using boolean expressions. The proposed method consists of two stages. In the first stage we find the set of SNPs involved in the development of diseases using mutual information based on entropy. In the second stage we find the highest accuracy boolean expression that consists of the SNP set obtained in the first stage. We experimented with clinical data to demonstrate the effectiveness of the proposed method. We also compared the differences between our method and the previous results on the SNP associations studies.
KW - 복합질환(complex diseases);단일염기다형성(single nucleotide polymorphism; SNP);부울식(boolean expressions);엔트로피(entropy);상호정보(mutual information)
DO -
UR -
ER -

임상섭 and Kyubum Wee. (2010). Prediction of SNP interactions in complex diseases with mutual information and boolean algebra. Journal of The Korea Society of Computer and Information, 15(11), 215-224.

임상섭 and Kyubum Wee. 2010, "Prediction of SNP interactions in complex diseases with mutual information and boolean algebra", Journal of The Korea Society of Computer and Information, vol.15, no.11 pp.215-224.

임상섭, Kyubum Wee "Prediction of SNP interactions in complex diseases with mutual information and boolean algebra" Journal of The Korea Society of Computer and Information 15.11 pp.215-224 (2010) : 215.

임상섭, Kyubum Wee. Prediction of SNP interactions in complex diseases with mutual information and boolean algebra. 2010; 15(11), 215-224.

임상섭 and Kyubum Wee. "Prediction of SNP interactions in complex diseases with mutual information and boolean algebra" Journal of The Korea Society of Computer and Information 15, no.11 (2010) : 215-224.

임상섭; Kyubum Wee. Prediction of SNP interactions in complex diseases with mutual information and boolean algebra. Journal of The Korea Society of Computer and Information, 15(11), 215-224.

임상섭; Kyubum Wee. Prediction of SNP interactions in complex diseases with mutual information and boolean algebra. Journal of The Korea Society of Computer and Information. 2010; 15(11) 215-224.

임상섭, Kyubum Wee. Prediction of SNP interactions in complex diseases with mutual information and boolean algebra. 2010; 15(11), 215-224.

임상섭 and Kyubum Wee. "Prediction of SNP interactions in complex diseases with mutual information and boolean algebra" Journal of The Korea Society of Computer and Information 15, no.11 (2010) : 215-224.