Objectives: This study aimed to examine the factors affecting the resilience of emotional intelligence, self-esteem, and social support of clinical dental hygienists. Methods: Participants were 200 clinical dental hygienists. Data were collected from June to August, 2022 and analyzed using PASW Statistics 26.0. Results: The mean scores for resilience, emotional intelligence, self-esteem and social support were 3.66, 3.59, 3.69 and 4.04 respectively. Significant differences were observed in the level of resilience between marital status, educational level, monthly income, and work intensity of the clinical dental hygienists (p <0.05). Resilience showed a significant relationship with self-esteem (r=0.664), social support (r=0.626), and emotional intelligence (r=0.732). The results of the multiple regression analysis showed that social support was the strongest predictor of resilience, explaining 42.9% of the total variance (F=38.440, p <0.001). Conclusions: The findings suggest that efforts should be made to increase social support that affects the resilience of clinical dental hygienists.