Effect of autophagy in human tongue squamous cell carcinoma SCC 25 cells from Scutellariae Radix by ethanol extract (에탄올에 의해 추출한 황금이 구강암 세포에서 나타나는 자가포식작용)

최별보라

doi:10.13065/jksdh.2014.14.02.287

Effect of autophagy in human tongue squamous cell carcinoma SCC 25 cells from Scutellariae Radix by ethanol extract

Journal of Korean society of Dental Hygiene
Abbr : J Korean Soc Dent Hyg
2014, 14(2), pp.287~292
DOI : 10.13065/jksdh.2014.14.02.287
Publisher : Korean Society of Dental Hygiene
Research Area : Medicine and Pharmacy > Dentistry

최별보라 ¹

¹동서대학교

Accredited

ABSTRACT

Objectives : The purpose of the study is to examine the cell growth effect and autophagyeffect of Scutellariae Radix by ethanol extract in SCC 25 cells. Methods : Cell growth inhibitory effect and autophagy induced by Scutellariae Radix wereconfirmed by WST-1 assay, monodansylcadaverine(MDC) stain, and flow cytometry by acridineorange(AO) stain. Results : The Scutellariae Radix treatment decreased the cell proliferation in a dose and timedependent manner. Scutellariae Radix has anticancer effects that autophagic vacuoles were apparentby MDC and AO staining in SCC 25 cells. Conclusions : Scutellariae Radix showed anticancer activity against SCC 25 cells via autophagy. The data provided the possibility that Scutellariae Radix may potentially contribute to oral cancertreatment.

KEYWORDS

autophagy, Scutellariae Radix, squamous cell carcinoma

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