@article{ART003352327},
author={Kyung Hee Lee},
title={Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model},
journal={Journal of Korean society of Dental Hygiene},
issn={2287-1705},
year={2026},
volume={26},
number={3},
pages={319-327},
doi={10.13065/jksdh.2026.26.3.5}
TY - JOUR
AU - Kyung Hee Lee
TI - Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model
JO - Journal of Korean society of Dental Hygiene
PY - 2026
VL - 26
IS - 3
PB - Korean Society of Dental Hygiene
SP - 319
EP - 327
SN - 2287-1705
AB - Objectives: To evaluate the effects of mineral trioxide aggregate (MTA) application after pulp injury amplified excitability in the trigeminal ganglion (TG) using electrophysiological optical imaging. Beyond simple pulp shielding, the therapeutic potential of MTA lies in inhibiting pain-related signal transmission and alleviating ganglion-level sensitization associated with pulpitis pain. Methods: Pulpitis was induced using allyl isothiocyanate in C57BL/6 mice. MTA was applied to the exposed pulp after pulp injury. Neuronal activity in the TG was recorded using voltage-sensitive dye-based optical imaging. The expression of inflammation-related molecules and pain-associated pathways protein was evaluated by western blot analysis. Results: Optical imaging demonstrated that the MTA-treated group showed markedly reduced spatiotemporal neural activity compared with the pulpitis group. The activated area was also reduced, indicating attenuation of pulpitis-induced TG sensitization. In the TG, the pulpitis group exhibited significantly increased expression of the inflammatory pain factors. TRPV1 and pERK, which are associated with pain sensitization, compared with the control group. In contrast, the MTA-treated group showed significantly reduced expression of these pain-related proteins. Conclusions: These findings suggest that MTA may serve as an effective therapeutic strategy in root canal treatment and in reducing pain-related signaling activity.
KW - MTA cement;Pain;Pulpitis;Sensitization;Trigeminal ganglion
DO - 10.13065/jksdh.2026.26.3.5
ER -
Kyung Hee Lee. (2026). Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model. Journal of Korean society of Dental Hygiene, 26(3), 319-327.
Kyung Hee Lee. 2026, "Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model", Journal of Korean society of Dental Hygiene, vol.26, no.3 pp.319-327. Available from: doi:10.13065/jksdh.2026.26.3.5
Kyung Hee Lee "Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model" Journal of Korean society of Dental Hygiene 26.3 pp.319-327 (2026) : 319.
Kyung Hee Lee. Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model. 2026; 26(3), 319-327. Available from: doi:10.13065/jksdh.2026.26.3.5
Kyung Hee Lee. "Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model" Journal of Korean society of Dental Hygiene 26, no.3 (2026) : 319-327.doi: 10.13065/jksdh.2026.26.3.5
Kyung Hee Lee. Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model. Journal of Korean society of Dental Hygiene, 26(3), 319-327. doi: 10.13065/jksdh.2026.26.3.5
Kyung Hee Lee. Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model. Journal of Korean society of Dental Hygiene. 2026; 26(3) 319-327. doi: 10.13065/jksdh.2026.26.3.5
Kyung Hee Lee. Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model. 2026; 26(3), 319-327. Available from: doi:10.13065/jksdh.2026.26.3.5
Kyung Hee Lee. "Attenuation of trigeminal ganglion sensitization by mineral trioxide aggregate treatment in a pulpitis model" Journal of Korean society of Dental Hygiene 26, no.3 (2026) : 319-327.doi: 10.13065/jksdh.2026.26.3.5
