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Adjunctive effects of combined Lacticaseibacillus rhamnosus DM163 and Lactobacillus plantarum DSR920 following scaling and root planing in patients with mild gingivitis: a randomized, double-blind pilot clinical trial

  • Journal of Korean society of Dental Hygiene
  • Abbr : J Korean Soc Dent Hyg
  • 2026, 26(3), pp.307~318
  • DOI : 10.13065/jksdh.2026.26.3.4
  • Publisher : Korean Society of Dental Hygiene
  • Research Area : Medicine and Pharmacy > Dentistry
  • Received : January 20, 2026
  • Accepted : June 5, 2026
  • Published : June 30, 2026

Mu-Yeol Cho 1,  Je-Hyun Eom 2,  Ji-Won Kim 2,  Yun-Woo Kim 2,  Seung-Jo Yang 3,  Jeong-Hoo Lee 3,  Hye-Sung Kim 4,  Jinhyeuk Lee 5,  Inseong Hwang 2,  Young Youn Kim 4

1Apple Tree Institute of Biomedical Science, Apple Tree Medical Foundatio
2Apple Tree Institute of Biomedical Science, Apple Tree Medical Foundation
3Docsmedi Co., Ltd.
4Apple Tree Dental Hospital, Apple Tree Medical Foundation
5Daesang Wellife Co., Ltd.

Accredited

ABSTRACT

Objectives: This pilot trial evaluated the adjunctive effects of combined Lacticaseibacillus rhamnosus DM163 and Lactobacillus plantarum DSR920 following scaling and root planing (SRP) on periodontal parameters, oral microbiota, and safety in patients with mild gingivitis. Methods: Thirty participants with mild gingivitis were enrolled in this single-center, double-blind, randomized pilot trial. After SRP, the participants received either probiotics or a placebo for 12 weeks. Clinical parameters, oral bacteria detected by qPCR, serum inflammatory biomarkers, and safety outcomes were assessed. Results: Twenty-seven participants were included in the analysis (test group n=14, placebo group n=13). No statistically significant between-group or within-group changes were observed in any of the clinical periodontal parameters. Treponema denticola increased in the 6-week mouthwash samples in the placebo group (p=0.005), while Fusobacterium nucleatum increased in the 12-week plaque samples in the test group (p=0.009). Overall, no consistent reduction in major periodontal pathogens was observed. Most serum inflammatory biomarkers remained below the detection limits, and no serious adverse events occurred. Conclusions: In the present post-SRP mild gingivitis setting, the adjunctive use of probiotics was well tolerated but did not demonstrate statistically significant clinical or microbiological effects. Future trials should optimize baseline standardization and statistical power, and incorporate gingival crevicular fluid analysis. Trial registration: KCT0009762.

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