Purpose: The study aimed to determine the mediating effect of resilience in the association perception of interpersonal stress, burnout, and job satisfaction among emergency room nurses. Methods: Data were collected from June 15 to July 31, 2018. The study was conducted on 187 emergency room nurses with more than six months of medical care experience and were included in the selection criteria in 10 hospitals in Busan, Yangsan, and Changwon. Four instruments were used: Job stress, Copenhagen Burnout Inventory (CBI), Job satisfaction, and Connor Davidson-Resilience Scale (CD-RISC). Data were analyzed with descriptive statistics, independent t-test, one-way ANOVA, Pearson's Correlation, Sobel test, and multiple regression analysis using the IBM SPSS Statistics 21.0 program. Results: It was found that resilience had significant differences according to marital status (t=-2.97, p=.003), religion (t=2.15, p=.033), education level (t=-3.79, p<.001), and monthly income (F=5.13, p=.007). The analysis of the mediating effect of resilience between emergency room nurses' interpersonal stress and burnout showed that resilience had a significant partial mediating effect (Z=2.03, p=.043). The analysis of the mediating effect of resilience between emergency room nurses’ interpersonal stress and job satisfaction showed that resilience had a significant partial mediating effect (Z=-2.47 p=.014). Conclusion: This study proposes developing a program to reduce and manage the interpersonal stress of emergency room nurses by improving resilience by confirming the mediating effect of resilience in the relationship between interpersonal stress and exhaustion and job satisfaction for emergency room nurses.