@article{ART000952086},
author={김대성 and 이명우 and 노유헌 and 이도연 and 이현정 and Bach JH and 한정우 and 이광길 and 여주홍 and Lee Won Bok and Sung Su Kim},
title={Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2004},
volume={17},
number={3},
pages={231-240},
doi={10.11637/aba.2004.17.3.231}
TY - JOUR
AU - 김대성
AU - 이명우
AU - 노유헌
AU - 이도연
AU - 이현정
AU - Bach JH
AU - 한정우
AU - 이광길
AU - 여주홍
AU - Lee Won Bok
AU - Sung Su Kim
TI - Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death
JO - Anatomy & Biological Anthropology
PY - 2004
VL - 17
IS - 3
PB - 대한체질인류학회
SP - 231
EP - 240
SN - 2671-5651
AB - In this present study, we show that 3HK-induced reactive oxygen species (ROS) accumulation and caspase activation
lead to apoptotic cell death. Pretreatment with N-acetylcysteine (NAC), an effective antioxidant, significantly attenuated
3HK-induced apoptosis by way of a reduction of ROS accumulation and caspase activity. SKN-SN cells were protected
from 3HK-induced cytotoxicity by heat shock protein (HSP). HSP90 effectively attenuated 3HK-mediated ROS
accumulation and apoptosis. In addition, the protective effect of HSP90 was abolished by pretreatment with HSP90 antisense
oligonucleotide, but not when pretreated with anti-senses for other HSPs. These results suggest that HSP90
protects SKN-SH cells from 3HK-induced cytotoxicity by reducing ROS levels and caspase activity.
KW - 3-Hydroxykynurenine (3HK);Heat shock protein 90 (HSP90);Reactive oxygen species (ROS);Caspase;
DO - 10.11637/aba.2004.17.3.231
ER -
김대성, 이명우, 노유헌, 이도연, 이현정, Bach JH, 한정우, 이광길, 여주홍, Lee Won Bok and Sung Su Kim. (2004). Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death. Anatomy & Biological Anthropology, 17(3), 231-240.
김대성, 이명우, 노유헌, 이도연, 이현정, Bach JH, 한정우, 이광길, 여주홍, Lee Won Bok and Sung Su Kim. 2004, "Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death", Anatomy & Biological Anthropology, vol.17, no.3 pp.231-240. Available from: doi:10.11637/aba.2004.17.3.231
김대성, 이명우, 노유헌, 이도연, 이현정, Bach JH, 한정우, 이광길, 여주홍, Lee Won Bok, Sung Su Kim "Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death" Anatomy & Biological Anthropology 17.3 pp.231-240 (2004) : 231.
김대성, 이명우, 노유헌, 이도연, 이현정, Bach JH, 한정우, 이광길, 여주홍, Lee Won Bok, Sung Su Kim. Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death. 2004; 17(3), 231-240. Available from: doi:10.11637/aba.2004.17.3.231
김대성, 이명우, 노유헌, 이도연, 이현정, Bach JH, 한정우, 이광길, 여주홍, Lee Won Bok and Sung Su Kim. "Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death" Anatomy & Biological Anthropology 17, no.3 (2004) : 231-240.doi: 10.11637/aba.2004.17.3.231
김대성; 이명우; 노유헌; 이도연; 이현정; Bach JH; 한정우; 이광길; 여주홍; Lee Won Bok; Sung Su Kim. Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death. Anatomy & Biological Anthropology, 17(3), 231-240. doi: 10.11637/aba.2004.17.3.231
김대성; 이명우; 노유헌; 이도연; 이현정; Bach JH; 한정우; 이광길; 여주홍; Lee Won Bok; Sung Su Kim. Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death. Anatomy & Biological Anthropology. 2004; 17(3) 231-240. doi: 10.11637/aba.2004.17.3.231
김대성, 이명우, 노유헌, 이도연, 이현정, Bach JH, 한정우, 이광길, 여주홍, Lee Won Bok, Sung Su Kim. Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death. 2004; 17(3), 231-240. Available from: doi:10.11637/aba.2004.17.3.231
김대성, 이명우, 노유헌, 이도연, 이현정, Bach JH, 한정우, 이광길, 여주홍, Lee Won Bok and Sung Su Kim. "Down-regulated reactive oxygen species by heat shock protein 90 in 3-Hydroxykynurenine-induced SKN-SH cell death" Anatomy & Biological Anthropology 17, no.3 (2004) : 231-240.doi: 10.11637/aba.2004.17.3.231
