The Effect of Myocardial Infarction on the Reproductive Function in Adult Male Rats (수컷 흰쥐에서 심근경색이 번식기능에 미치는 영향)

Hyun-Jin Tae (태현진); 문진희; YU, IL JEOUNG (유일정); 박진호; Lee Young-Hoon (이영훈); 안동춘; 강형섭; 박영재; Yang,Hong-Hyun (양홍현); 김인식

doi:10.11637/aba.2006.19.3.191

The Effect of Myocardial Infarction on the Reproductive Function in Adult Male Rats

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2006, 19(3), pp.191~203
DOI : 10.11637/aba.2006.19.3.191
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

Hyun-Jin Tae ¹, 문진희 ¹, YU, IL JEOUNG ¹, 박진호 ², Lee Young-Hoon ¹, 안동춘 ¹, 강형섭 ³, 박영재 ¹, Yang,Hong-Hyun ¹, 김인식 ³

¹전북대학교
²강원대학교
³헬스케어사업단

Accredited

ABSTRACT

The present study was to investigate in more detail the changes of reproductive function in the male rat following myocardial infarction (MI). Ligation of the left coronary artery was performed in male Sprague-Dawley male rats at 60 days of age. Control rats were obtained sham-operated animals. MI rats were sacrificed at 1, 3, 5, 7, 14, and 30 day after ligation of left anterior descending coronary artery. Control rats were sacrificed on 30 day after thoracotomy. Myocardial infarct size was assessed by planimetry and perimetry. Testes of rats were fixed by whole body perfusion using a fixative containing 2.5% glutaraldehyde in cacodylate buffer, processed and embedded in Epon-araldite. Using 1 µm sections stained with methylene blue-azure II, qualitative and quantitative (stereological) morphological studies were performed. Testosterone levels in the incubation medium of luteinizing hormone-stimulated (100 ng/mL) testosterone secretion per testis in vitro, and in serum were determined by radioimmunoassay. Sperm production was measured by routine technique. Mean infarct size was 29.5~33.5% of the left ventricle after coronary occlusion in experimental groups. No changes were observed in testis volume, absolute volume of Leydig cell, Leydig cell size, and number of Leydig cell per testis in MI rats compared to sham-operated animals. Serum testosterone, LH-stimulated testicular testosterone production, and daily sperm production in MI rats were not significantly different (P¤0.05) from sham-operated animals. These results demonstrate that under the experimental conditions employed here, experimental chronic myocardial infarction does not exert adverse effects on the reproductive function of male rats.

KEYWORDS

Male rat, Myocardial infarction, Reproductive function

Citation status

* References for papers published after 2023 are currently being built.

[journal] / 1995. / Effect of androgens oncoronary artery atherosclerosis and atherosclerosis relatedimpairment of vascular responsiveness. 15 : 562~570

[journal] / 2003. / Induction of myocardial infarcts of a predictable sizeand location by branch pattern probability-assisted coronaryligation in C57BL/6 mice. 286 : 1201~1207

[journal] / 1996. / The relationship of natural androgens to coronary artery disease in male: A review / 125 : 1~13

[journal] / 2000. / Changes in the testis interstitium Sprague Dawley rats from birth to sexual maturity. 62 : 680~690

[journal] / 2003. / Theeffect on sperm production in adult Sprague-Dawley ratsexposed bisphenol. 74 : 129~138

[journal] / 19897. / Usefulness of sex steroidhormone levels in predicting coronary artery disease inmen. Am J Cardiol 60 : 771~777

[journal] / 1994. / Age-relateddecreased Leydig cell testosterone production in the brownnorway rat. J Androl 15 : 551~557

[journal] / 1999. / Long-term suppression of Leydig cellstetoidogenesis prevents Leydig cell aging. 96 : 14877~14881

[journal] / 198-2361972 / Kinetics of spermatogenesis in mammals

[journal] / 1991. / Increased spermproduction in adult rats after transient neonatal hypothyroidism.Endocrinology 129 : 244~248

[journal] / 1994. / Triiodothyrinine inhibitsproliferation and stimulates differentiation of culturedneonatal Sertoli cells possible mechanism for increasedadult testis weight and sperm production induced byneonatal goitrogrn treatment. Biol Reprod 51 : 1000~1005

[journal] / 2000. / Men with coronaryartery disease have lower levels of androgens than menwith normal coronary angiograms. 21 : 890~894

[journal] / 1993. / and coronary heart disease risk in hyperlipidemicmen. J Lab Clin Med 122 endoge fibri(us testosterone lysis) : 412~420

[journal] / 1996. / The age related decline of androgen levels inmen 78 : 763~768

[journal] / 191-2001994. / Adrenal androgenand testosterone as coronary artery risk factor in the Helsinkiheart study. Atherosclerosis 105

[journal] / 2000. / Experimental models for the studyof cardiovascular function and disease. 41 : 597~603

[journal] / 1986. / Spermatogenesis and aging in the human. JAndrol 7 : 331~354

[journal] / 1988. / A light microscopic and morphometric analysis ofthe Sertoli cell during the spermatogenic cycle of the rat.Anat Embryol 177 : 341~348

[journal] / 2002. / Changes in the testis interstitium of Brown Norway ratswith aging and effects of luteinizing and thyroid hormoneson the aged testes in enhancing the steroidogenic potential. 66 : 1359~1366

[journal] / 1999. / Morphometric study of the testicularinterstitium of the rat during postnatal development. 32 : 849~858

[journal] / 1998. / Changes of plasma testosterone level inmale patients with coronary heart disease. 105 : 191~200

[journal] / 1982. / Relationship between sexhormones : 42~44

[journal] / 2001. / Differentiationof the adult Leydig cell population in the postnatal testis. 65 : 660~671

[journal] / 1990. / Sources of error inthe estimation of Leydig cell numbers in control and atrophiedmammalian testes. J Microsc 59 : 73~82

[journal] / 1990. / Experimental cryptorchidism in the adult mouse. J Androl11 : 539~547

[journal] / 1987. / Morphometric analysis of the components of the neonataland the adult rat testis interstitium. Int J Androl 10 : 525~534

[journal] / 1994. / Effects of neonataladministration of the reversible goitrogen propylthiouracilon the testis interstitium in adult rats. J Reprod Fert 100 : 85~92

[journal] / 1998. / Effectsof chronic lutenizing hormone treatment on Leydig cellstructure and function in adult rats. 30 : 64~73

[journal] / 1988. / Comparisonof components of the testis interstitium with testosteronesecretion hamster : 12~22

[journal] / 1999. / The effect of cardiac arrest on the permeabilityof the mouse blood-testis barrier to adenylate cyclaseactivating polypeptide. Peptide 20 : 1337~1340

[journal] / 1980.mudersf2000. / Morphometric analysis of Leydigcells in the normal rat testis. Animal models of chronic heart failure.Pharmacol Res 41 84 : 340 606~354 612

[journal] / 2002. / Effect of dihydrotestosteronetreatment on exercise induced ischemia in men wishstable ischemic heart disease. 9 : 533~534

[journal] / 1995. / Regulation of expression ofsteroidogenic enzymes in Leydig cells. 52 : 217~225

[journal] / 1991. / Progressiveventricular remodeling in rat with myocardialinfarction. Heart Circ Physiol 29 : 1406~1414

[journal] / 1976. / Effects of aging on LH and prolactinafter LHRH methyldopa and stress in the malerat. Proc Soc Exp Biol Med 151 : 507~511

[journal] / 1978. / Peripheral metabolism of testosteroneduring puberty in the male guinea-pig. Reprod Fert 53 : 273~276

[journal] / 1999. / Acute antiischemiceffect of testosterone in men with coronary artery disease. 99 ( ) : 1666~1670

[journal] / 1995. / Building a testis. 27 : 129~147

[journal] / 1994. / Testosterone treatmentenhances thromboxane A2 minetic induced coronary arteryvasoconstriction in guinea pigs. Eur J Clin Invest 24 : 20~52

[journal] / 1999. / Effect of testosteroneon coronary vasomotor regulation in men with coronaryheart disease. 100 : 1690~1696

[journal] / 2000. / Regulation of Leydig cell steroidogenicfunction during aging. 63 : 977~981

[journal] / 2000 / Animal models of chronic heart failure 41 : 606~612

KJCKorea
Journal Central

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

The Effect of Myocardial Infarction on the Reproductive Function in Adult Male Rats

ABSTRACT

KEYWORDS

Citation status

* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

The Effect of Myocardial Infarction on the Reproductive Function in Adult Male Rats

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (0)

REFERENCES (42) * References for papers published after 2023 are currently being built.

Search PDF

Citation

* References for papers published after 2023 are currently being built.