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@article{ART001142784},
author={류지원 and 길영기 and 최병태},
title={Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2006},
volume={19},
number={3},
pages={215-222},
doi={10.11637/aba.2006.19.3.215}

TY - JOUR
AU - 류지원
AU - 길영기
AU - 최병태
TI - Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model
JO - Anatomy & Biological Anthropology
PY - 2006
VL - 19
IS - 3
PB - 대한체질인류학회
SP - 215
EP - 222
SN - 2671-5651
AB - To examine the effects of electroacupuncture (EA) on central nociceptive modulation, expressional changes of spinal neuronal nitric oxide synthase (nNOS) were investigated in complete Freund’s adjuvant (CFA)-injected rats. Inflammation was induced by an intraplantar injection of CFA into the hindpaw of male Sprague-Dawley rats. Bilateral EA stimulation at 2 Hz, 15 Hz and 120 Hz was applied at those acupoints corresponding to Zusanli and Sanyinjiao in man with 3-day intervals for 30 days. At 30 days after CFA-injection, effects of EA on nNOS expression were observed in the dorsal horn of the spinal cord using immunohistochemical methods. The mean integrated optical density of nNOS immunoreaction was significantly increased in the dorsal horn throughout L1 to L5 lumbar segments in CFA-injected rats. The nNOS expression was attenuated in all regions of the dorsal horn by all types of EA. Especially, these reaction was markedly decreased in the superficial laminae and nucleus proprius of L1 and L3 lumbar segments by three types of EA, but a marked decrease in the neck of the dorsal horn was observed only in 2 Hz stimulation. The marked decrease of nNOS also showed in nucleus proprius and the neck of L5 lumbar segments in 2 Hz and 15 Hz EA stimulated rats. It is concluded that EA treatment can attenuate chronic inflammatory process in CFA-injected rats through modulating expression of nNOS in the dorsal horn of the spinal cord.
KW - Electroacupuncture;Nitric oxide synthase;Complete Freund’s adjuvant;Spinal cord
DO - 10.11637/aba.2006.19.3.215
ER -

류지원, 길영기 and 최병태. (2006). Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model. Anatomy & Biological Anthropology, 19(3), 215-222.

류지원, 길영기 and 최병태. 2006, "Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model", Anatomy & Biological Anthropology, vol.19, no.3 pp.215-222. Available from: doi:10.11637/aba.2006.19.3.215

류지원, 길영기, 최병태 "Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model" Anatomy & Biological Anthropology 19.3 pp.215-222 (2006) : 215.

류지원, 길영기, 최병태. Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model. 2006; 19(3), 215-222. Available from: doi:10.11637/aba.2006.19.3.215

류지원, 길영기 and 최병태. "Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model" Anatomy & Biological Anthropology 19, no.3 (2006) : 215-222.doi: 10.11637/aba.2006.19.3.215

류지원; 길영기; 최병태. Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model. Anatomy & Biological Anthropology, 19(3), 215-222. doi: 10.11637/aba.2006.19.3.215

류지원; 길영기; 최병태. Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model. Anatomy & Biological Anthropology. 2006; 19(3) 215-222. doi: 10.11637/aba.2006.19.3.215

류지원, 길영기, 최병태. Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model. 2006; 19(3), 215-222. Available from: doi:10.11637/aba.2006.19.3.215

류지원, 길영기 and 최병태. "Effects of Electroacupuncture on the Expression of Spinal Neuronal Nitric Oxide Synthase in Adjuvant-induced Arthritic Rat Model" Anatomy & Biological Anthropology 19, no.3 (2006) : 215-222.doi: 10.11637/aba.2006.19.3.215