@article{ART001143847},
author={고창용 and 우대곤 and 김한성 and 이법이},
title={Micro --CT Evaluation in Osteoporosis Model},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2005},
volume={18},
number={4},
pages={283-290},
doi={10.11637/aba.2005.18.4.283}
TY - JOUR
AU - 고창용
AU - 우대곤
AU - 김한성
AU - 이법이
TI - Micro --CT Evaluation in Osteoporosis Model
JO - Anatomy & Biological Anthropology
PY - 2005
VL - 18
IS - 4
PB - 대한체질인류학회
SP - 283
EP - 290
SN - 2671-5651
AB - Osteoporosis is a major health-care problem for aging communities. And postmenopausal osteoporosis is a common disorder characterized by an increase in bone resorption relative to bone formation, generally in conjunction with an increased rate of bone turnover.Twenty female rats were used as rat model of osteoporosis. They randomly were divided into two groups:a normal control group, and calcium-free diet groups treated with bilateral ovariectomy. The animals were sacrified at 12 weeks after treatment. In the rats with osteoporosis, there was significant thining and loss of trabeculae, accompanied by a disconnection of trabeculae. And acid mucopolysaccharides were decreased in osteoporotic animals. In order to setup conditions of invivo micro-CT, proper anesthetic is ketamine (50 mg/kg)/xylazine (6 mg/kg). And proper breathing rate of experimental animals is 1.3~1.6/sec. Our finding suggest that bilateral ovariectomy and calcium-free diet induce decrease in thickeness of trabecular bone and decrease in acid mucopolysaccharide, therefore cause weakness of bone. And micro-CT imaging system is useful to evaluate trabecular bone. Anesthetic time, anesthetics and respiration rate also signify much in micro-CT imaging system.
KW - In -vivo;Micro-CT;Osteoporosis;Trabecular bone;Ovariectomy
DO - 10.11637/aba.2005.18.4.283
ER -
고창용, 우대곤, 김한성 and 이법이. (2005). Micro --CT Evaluation in Osteoporosis Model. Anatomy & Biological Anthropology, 18(4), 283-290.
고창용, 우대곤, 김한성 and 이법이. 2005, "Micro --CT Evaluation in Osteoporosis Model", Anatomy & Biological Anthropology, vol.18, no.4 pp.283-290. Available from: doi:10.11637/aba.2005.18.4.283
고창용, 우대곤, 김한성, 이법이 "Micro --CT Evaluation in Osteoporosis Model" Anatomy & Biological Anthropology 18.4 pp.283-290 (2005) : 283.
고창용, 우대곤, 김한성, 이법이. Micro --CT Evaluation in Osteoporosis Model. 2005; 18(4), 283-290. Available from: doi:10.11637/aba.2005.18.4.283
고창용, 우대곤, 김한성 and 이법이. "Micro --CT Evaluation in Osteoporosis Model" Anatomy & Biological Anthropology 18, no.4 (2005) : 283-290.doi: 10.11637/aba.2005.18.4.283
고창용; 우대곤; 김한성; 이법이. Micro --CT Evaluation in Osteoporosis Model. Anatomy & Biological Anthropology, 18(4), 283-290. doi: 10.11637/aba.2005.18.4.283
고창용; 우대곤; 김한성; 이법이. Micro --CT Evaluation in Osteoporosis Model. Anatomy & Biological Anthropology. 2005; 18(4) 283-290. doi: 10.11637/aba.2005.18.4.283
고창용, 우대곤, 김한성, 이법이. Micro --CT Evaluation in Osteoporosis Model. 2005; 18(4), 283-290. Available from: doi:10.11637/aba.2005.18.4.283
고창용, 우대곤, 김한성 and 이법이. "Micro --CT Evaluation in Osteoporosis Model" Anatomy & Biological Anthropology 18, no.4 (2005) : 283-290.doi: 10.11637/aba.2005.18.4.283
