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@article{ART001144000},
author={이도연 and 이현정 and 노유헌 and 윤지영 and 한인숙 and Chung Yoon Hee and 김경용 and 김성수 and 이원복},
title={Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2006},
volume={19},
number={1},
pages={49-59},
doi={10.11637/aba.2006.19.1.49}

TY - JOUR
AU - 이도연
AU - 이현정
AU - 노유헌
AU - 윤지영
AU - 한인숙
AU - Chung Yoon Hee
AU - 김경용
AU - 김성수
AU - 이원복
TI - Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death
JO - Anatomy & Biological Anthropology
PY - 2006
VL - 19
IS - 1
PB - 대한체질인류학회
SP - 49
EP - 59
SN - 2671-5651
AB - Ceramide induces cell death in a dose- and time-dependent manner in neuroblastoma SK-N-SH cells. To investigate the mechanism of SK-N-SH cell death by C2-ceramide, morphological features and Hoechst 33258 staining were analyzed. In these morphlogic study the cell death by ceramide showed typical apoptotic features, nuclear condensation,fragmentation, and membrane blebbing. Ceramide-induced apoptosis was accompanied by nuclear accumulation of p53. Inhibition of p53 expression with p53 antisense oligonucleotides inhibited apoptosis evoked by ceramide. Also, ceramide induced mitochondrial event, collapse of mitochondrial membrane potential (∆ψm) and interestingly, inhibition of p53 attenuated collapse of mitochondrial membrane potential, suggests that ceramide induces mitochondrial dysfunction through upregulation of p53 expression. These results suggest that ceramide-induced apoptosis is dependent upon increase in cellular p53 levels which play a critical role in the regulation of apoptotic cell death and p53 modulates mitochondrial function such as mitochondrial membrane potential level.
KW - Ceramide;Apoptosis;SK-N-SH;p53;Mitochondrial membrane potential (MMP)
DO - 10.11637/aba.2006.19.1.49
ER -

이도연, 이현정, 노유헌, 윤지영, 한인숙, Chung Yoon Hee, 김경용, 김성수 and 이원복. (2006). Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death. Anatomy & Biological Anthropology, 19(1), 49-59.

이도연, 이현정, 노유헌, 윤지영, 한인숙, Chung Yoon Hee, 김경용, 김성수 and 이원복. 2006, "Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death", Anatomy & Biological Anthropology, vol.19, no.1 pp.49-59. Available from: doi:10.11637/aba.2006.19.1.49

이도연, 이현정, 노유헌, 윤지영, 한인숙, Chung Yoon Hee, 김경용, 김성수, 이원복 "Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death" Anatomy & Biological Anthropology 19.1 pp.49-59 (2006) : 49.

이도연, 이현정, 노유헌, 윤지영, 한인숙, Chung Yoon Hee, 김경용, 김성수, 이원복. Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death. 2006; 19(1), 49-59. Available from: doi:10.11637/aba.2006.19.1.49

이도연, 이현정, 노유헌, 윤지영, 한인숙, Chung Yoon Hee, 김경용, 김성수 and 이원복. "Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death" Anatomy & Biological Anthropology 19, no.1 (2006) : 49-59.doi: 10.11637/aba.2006.19.1.49

이도연; 이현정; 노유헌; 윤지영; 한인숙; Chung Yoon Hee; 김경용; 김성수; 이원복. Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death. Anatomy & Biological Anthropology, 19(1), 49-59. doi: 10.11637/aba.2006.19.1.49

이도연; 이현정; 노유헌; 윤지영; 한인숙; Chung Yoon Hee; 김경용; 김성수; 이원복. Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death. Anatomy & Biological Anthropology. 2006; 19(1) 49-59. doi: 10.11637/aba.2006.19.1.49

이도연, 이현정, 노유헌, 윤지영, 한인숙, Chung Yoon Hee, 김경용, 김성수, 이원복. Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death. 2006; 19(1), 49-59. Available from: doi:10.11637/aba.2006.19.1.49

이도연, 이현정, 노유헌, 윤지영, 한인숙, Chung Yoon Hee, 김경용, 김성수 and 이원복. "Study on the Mitochondrial Dysfunction by p53 Regulation inCeramide-induced Neuronal Cell Death" Anatomy & Biological Anthropology 19, no.1 (2006) : 49-59.doi: 10.11637/aba.2006.19.1.49