@article{ART001144053},
author={노유헌 and 이명우 and 김대성 and 이도연 and 김석원 and 강용구 and 손동섭 and Soon Cheol Park and 정윤희 and 김경용 and Sung Su Kim and Lee Won Bok},
title={The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2004},
volume={17},
number={3},
pages={187-196},
doi={10.11637/aba.2004.17.3.187}
TY - JOUR
AU - 노유헌
AU - 이명우
AU - 김대성
AU - 이도연
AU - 김석원
AU - 강용구
AU - 손동섭
AU - Soon Cheol Park
AU - 정윤희
AU - 김경용
AU - Sung Su Kim
AU - Lee Won Bok
TI - The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell
JO - Anatomy & Biological Anthropology
PY - 2004
VL - 17
IS - 3
PB - 대한체질인류학회
SP - 187
EP - 196
SN - 2671-5651
AB - Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) serves as an extracellular signal triggering
apoptosis in tumor cells. To characterize the molecular events involved in TRAIL-induced apoptotic signaling, we
investigated the role of extracellular signal-regulated kinase 1/2 (ERK1/2) in the apoptosis using HeLa cells. Here we
show that TRAIL pronounced ERK1/2 activation through a tyrosine kinase-dependent mechanism, subsequently
elevated anti-apoptotic Bcl-2 protein levels. Pretreatment with Genistein, an inhibitor of tyrosine kinase, significantly
attenuated ERK1/2 activation and enhanced cell death. Moreover, inhibition of ERK1/2 with PD98059 promoted
apoptotic cell death through the down-regulation of ERK1/2 activity and Bcl-2 protein levels. Taken together, our
results suggest that the activation of ERK1/2 via tyrosine kinase pathway plays a protective role as the mechanism of
cellular defense through the up-regulation of Bcl-2 protein levels in TRAIL-induced apoptosis.
KW - TRAIL;ERK1/2;Tyrosine kinase;Bcl-2 protein;Apoptosis.
DO - 10.11637/aba.2004.17.3.187
ER -
노유헌, 이명우, 김대성, 이도연, 김석원, 강용구, 손동섭, Soon Cheol Park, 정윤희, 김경용, Sung Su Kim and Lee Won Bok. (2004). The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell. Anatomy & Biological Anthropology, 17(3), 187-196.
노유헌, 이명우, 김대성, 이도연, 김석원, 강용구, 손동섭, Soon Cheol Park, 정윤희, 김경용, Sung Su Kim and Lee Won Bok. 2004, "The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell", Anatomy & Biological Anthropology, vol.17, no.3 pp.187-196. Available from: doi:10.11637/aba.2004.17.3.187
노유헌, 이명우, 김대성, 이도연, 김석원, 강용구, 손동섭, Soon Cheol Park, 정윤희, 김경용, Sung Su Kim, Lee Won Bok "The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell" Anatomy & Biological Anthropology 17.3 pp.187-196 (2004) : 187.
노유헌, 이명우, 김대성, 이도연, 김석원, 강용구, 손동섭, Soon Cheol Park, 정윤희, 김경용, Sung Su Kim, Lee Won Bok. The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell. 2004; 17(3), 187-196. Available from: doi:10.11637/aba.2004.17.3.187
노유헌, 이명우, 김대성, 이도연, 김석원, 강용구, 손동섭, Soon Cheol Park, 정윤희, 김경용, Sung Su Kim and Lee Won Bok. "The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell" Anatomy & Biological Anthropology 17, no.3 (2004) : 187-196.doi: 10.11637/aba.2004.17.3.187
노유헌; 이명우; 김대성; 이도연; 김석원; 강용구; 손동섭; Soon Cheol Park; 정윤희; 김경용; Sung Su Kim; Lee Won Bok. The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell. Anatomy & Biological Anthropology, 17(3), 187-196. doi: 10.11637/aba.2004.17.3.187
노유헌; 이명우; 김대성; 이도연; 김석원; 강용구; 손동섭; Soon Cheol Park; 정윤희; 김경용; Sung Su Kim; Lee Won Bok. The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell. Anatomy & Biological Anthropology. 2004; 17(3) 187-196. doi: 10.11637/aba.2004.17.3.187
노유헌, 이명우, 김대성, 이도연, 김석원, 강용구, 손동섭, Soon Cheol Park, 정윤희, 김경용, Sung Su Kim, Lee Won Bok. The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell. 2004; 17(3), 187-196. Available from: doi:10.11637/aba.2004.17.3.187
노유헌, 이명우, 김대성, 이도연, 김석원, 강용구, 손동섭, Soon Cheol Park, 정윤희, 김경용, Sung Su Kim and Lee Won Bok. "The activation of ERK1/2 via tryosine kinase pathway attenuates TRAIL-induced apoptosis in HeLa cell" Anatomy & Biological Anthropology 17, no.3 (2004) : 187-196.doi: 10.11637/aba.2004.17.3.187
