@article{ART001228659},
author={이충범 and Ha U Syn and 조대행 and 최재연 and 차정호},
title={The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2007},
volume={20},
number={4},
pages={321-329},
doi={10.11637/aba.2007.20.4.321}
TY - JOUR
AU - 이충범
AU - Ha U Syn
AU - 조대행
AU - 최재연
AU - 차정호
TI - The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney
JO - Anatomy & Biological Anthropology
PY - 2007
VL - 20
IS - 4
PB - 대한체질인류학회
SP - 321
EP - 329
SN - 2671-5651
AB - Interleukin-6 (IL-6) and its receptor are presumed to play important roles in the developing nervous system. However,
little is known about their potential role(s) in the developing kidney. To investigate this, we have studied the expression
of IL-6 and its receptor (IL-6R) in the developing rat kidney.
Kidneys from 16- (F16), 18- and 20-day-old (F20) fetuses, 1- (P1), 3- (P3), 7- (P7) and 14-day-old (P14) pups, and
adult rats were extracted. Renal expressions of IL-6 and its receptors were examined by immunohistochemistry and in
situ hybridization respectively.
Il-6 protein already appeared in F16. The early stage of renal development before birth, IL-6 showed strong immunoreactivity
in the ureteric bud, metanephric mesenchymal cells (MMC) and developing glomerulus. The expression
pattern of IL-6 in nephrogenic zone are very similar even after birth. In matured nephron after birth, IL-6 immunoreactivities
were detected in distal tubules strongly, and collecting ducts moderately and thick ascending limb weekly. IL-
6R hybridization signals have also already appeared in 16-day old fetal kidney. Before birth, IL-6R mRNAs were
expressed in ureteric bud, MMC and developing glomerulus. In the matured nephron after birth, IL-6R mRNA was
expressed in the thick ascending limb, distal tubules, collecting ducts and S3 segment of proximal tubule.
These results suggest that IL-6 and its receptor may be involved in regulation of nephron formation in nephrogenic
zone of rat, and play a role in distal nephron including collecting duct after birth.
KW - Nephrogenesis;Interleukin-6;Immunohistochemistry;In situ hybridization;Rat
DO - 10.11637/aba.2007.20.4.321
ER -
이충범, Ha U Syn, 조대행, 최재연 and 차정호. (2007). The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney. Anatomy & Biological Anthropology, 20(4), 321-329.
이충범, Ha U Syn, 조대행, 최재연 and 차정호. 2007, "The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney", Anatomy & Biological Anthropology, vol.20, no.4 pp.321-329. Available from: doi:10.11637/aba.2007.20.4.321
이충범, Ha U Syn, 조대행, 최재연, 차정호 "The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney" Anatomy & Biological Anthropology 20.4 pp.321-329 (2007) : 321.
이충범, Ha U Syn, 조대행, 최재연, 차정호. The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney. 2007; 20(4), 321-329. Available from: doi:10.11637/aba.2007.20.4.321
이충범, Ha U Syn, 조대행, 최재연 and 차정호. "The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney" Anatomy & Biological Anthropology 20, no.4 (2007) : 321-329.doi: 10.11637/aba.2007.20.4.321
이충범; Ha U Syn; 조대행; 최재연; 차정호. The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney. Anatomy & Biological Anthropology, 20(4), 321-329. doi: 10.11637/aba.2007.20.4.321
이충범; Ha U Syn; 조대행; 최재연; 차정호. The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney. Anatomy & Biological Anthropology. 2007; 20(4) 321-329. doi: 10.11637/aba.2007.20.4.321
이충범, Ha U Syn, 조대행, 최재연, 차정호. The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney. 2007; 20(4), 321-329. Available from: doi:10.11637/aba.2007.20.4.321
이충범, Ha U Syn, 조대행, 최재연 and 차정호. "The Expression of Interleukin-6 and Its Receptorin the Developing Rat Kidney" Anatomy & Biological Anthropology 20, no.4 (2007) : 321-329.doi: 10.11637/aba.2007.20.4.321
