Immunohistochemical Study on the Distribution of Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in the Central Nervous System of Adult Rats (Immunohistochemical Study on the Distribution of Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in the Central Nervous System of Adult Rats )

Hyunjeong Lee (이현정); 안향선; 박범준; 조대윤; Chung Yoon Hee (정윤희); 김대진; 김성수; Kyung-Yong Kim (김경용); Lee Won Bok (이원복)

doi:10.11637/aba.2008.21.4.381

Immunohistochemical Study on the Distribution of Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in the Central Nervous System of Adult Rats

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2008, 21(4), pp.381~390
DOI : 10.11637/aba.2008.21.4.381
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

Hyunjeong Lee ¹, 안향선 ¹, 박범준 ¹, 조대윤 ¹, Chung Yoon Hee ¹, 김대진 ¹, 김성수 ¹, Kyung-Yong Kim ¹, Lee Won Bok ¹

¹중앙대학교

Accredited

ABSTRACT

In the present study, we performed immunohistochemical studies to investigate the detailed distribution of insulin-like growth factor binding protein 7 (IGFBP7) in the central nervous system of adult rats. Twelve adult (4~6 month old) Sprague-Dawley rats were examined in this study. Immunohistochemistry using specific antibodies against IGFBP7 was performed in accordance with the free-floating method. In the present study, IGFBP7 immunoreactivity was observed in the cerebral cortex, hippocampus, brainstem, cerebellum and spinal cord. In the cerebral cortex, heavily stained neurons were seen in layers II-VI. In the hippocampus, pyramidal cells in CA1-3 region were strongly immunoreactive for IGFBP7. Strong immunoreactive neurons were also found in the supraoptic nucleus, paraventricular nucleus, periaqueductal gray and oculomotor nucleus. In the cerebellum, IGFBP7 immunoreactivity was prominent in the Purkinje cells and cerebellar output neurons. IGFBP7-immunoreactive neurons were prominent in the superior vestibular nucleus, cochlear nucleus, trigeminal motor nucleus, nucleus of the trapezoid, and facial nucleus. IGFBP7-immunoreactive neurons were also observed mainly in the anterior horn of the spinal cord. The first demonstration of IGFBP7 localization in the whole brain may provide useful data for the future investigations on the structural and functional properties of IGFBP7.

KEYWORDS

Insulin-like growth factor binding protein 7 (IGFBP7), 대뇌 겉질, 해마, 뇌줄기, 소뇌, 척수

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Immunohistochemical Study on the Distribution of Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in the Central Nervous System of Adult Rats

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* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Immunohistochemical Study on the Distribution of Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in the Central Nervous System of Adult Rats

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