@article{ART001328845},
author={김근철 and 김기정 and 이광호 and Park Ae Ja and 김경용 and 김애진 and 김재헌 and 다스제벡투멩 and 노맹석},
title={Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2009},
volume={22},
number={1},
pages={11-20},
doi={10.11637/aba.2009.22.1.11}
TY - JOUR
AU - 김근철
AU - 김기정
AU - 이광호
AU - Park Ae Ja
AU - 김경용
AU - 김애진
AU - 김재헌
AU - 다스제벡투멩
AU - 노맹석
TI - Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian
JO - Anatomy & Biological Anthropology
PY - 2009
VL - 22
IS - 1
PB - 대한체질인류학회
SP - 11
EP - 20
SN - 2671-5651
AB - As characterization of mitochondrial DNA (mtDNA) shows maternal inheritance and exists as more than thousands
copies per cell, it is widely used for population genetics and forensic scientific field. However, mitochondrial DNA study
has difficulties because heteroplasmy of mtDNA is being reported from coding and control region. In this study, we
have analyzed 200 samples to examine heteroplasmy in mitochondrial DNA of Korean and Mongolian.
The control region and coding region in mtDNA of blood from Koreans and Mongolians were analyzed with PCR
amplication and sequencing.
As a result, several heteroplasmy was observed from total 10 positions including 5 positions in coding region and 5
positions in control region, respectively. Moreover, it showed more than one heteroplasmy in coding region from 6
samples in Korean and 17 samples in Mongolian. Interestingly, heteroplasmy at 5178 position was shown in 6 samples
among 23 samples. Considering that the position is important for deciding haplogroup D, we suggest that additional
analysis on 4883 position needs for correct haplogrouping. Beside, we also found heteroplasmy in the other positions of
204, 4853, or 16249. Therefore, we suggest that it is required of combinatory analysis on several key nucleotide positions to obtain good
results when determining mitochondrial haplogroups.
KW - Heteroplasmy;East Asian;Haplogroup;Mitochondrial DNA;Coding region;Control region
DO - 10.11637/aba.2009.22.1.11
ER -
김근철, 김기정, 이광호, Park Ae Ja, 김경용, 김애진, 김재헌, 다스제벡투멩 and 노맹석. (2009). Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian. Anatomy & Biological Anthropology, 22(1), 11-20.
김근철, 김기정, 이광호, Park Ae Ja, 김경용, 김애진, 김재헌, 다스제벡투멩 and 노맹석. 2009, "Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian", Anatomy & Biological Anthropology, vol.22, no.1 pp.11-20. Available from: doi:10.11637/aba.2009.22.1.11
김근철, 김기정, 이광호, Park Ae Ja, 김경용, 김애진, 김재헌, 다스제벡투멩, 노맹석 "Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian" Anatomy & Biological Anthropology 22.1 pp.11-20 (2009) : 11.
김근철, 김기정, 이광호, Park Ae Ja, 김경용, 김애진, 김재헌, 다스제벡투멩, 노맹석. Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian. 2009; 22(1), 11-20. Available from: doi:10.11637/aba.2009.22.1.11
김근철, 김기정, 이광호, Park Ae Ja, 김경용, 김애진, 김재헌, 다스제벡투멩 and 노맹석. "Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian" Anatomy & Biological Anthropology 22, no.1 (2009) : 11-20.doi: 10.11637/aba.2009.22.1.11
김근철; 김기정; 이광호; Park Ae Ja; 김경용; 김애진; 김재헌; 다스제벡투멩; 노맹석. Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian. Anatomy & Biological Anthropology, 22(1), 11-20. doi: 10.11637/aba.2009.22.1.11
김근철; 김기정; 이광호; Park Ae Ja; 김경용; 김애진; 김재헌; 다스제벡투멩; 노맹석. Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian. Anatomy & Biological Anthropology. 2009; 22(1) 11-20. doi: 10.11637/aba.2009.22.1.11
김근철, 김기정, 이광호, Park Ae Ja, 김경용, 김애진, 김재헌, 다스제벡투멩, 노맹석. Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian. 2009; 22(1), 11-20. Available from: doi:10.11637/aba.2009.22.1.11
김근철, 김기정, 이광호, Park Ae Ja, 김경용, 김애진, 김재헌, 다스제벡투멩 and 노맹석. "Heteroplasmy of Mitochondrial DNA Shown in Korean and Mongolian" Anatomy & Biological Anthropology 22, no.1 (2009) : 11-20.doi: 10.11637/aba.2009.22.1.11
