Comparison of SNP Occurred in Coding Regions of Mitochondrial DNA Analyzed from Korean and Mongolian (사립체 DNA의 coding region에서 나타나는 한국인과 몽골인의 호발하는 염기서열변이 비교)

Kim Keun Cheol (김근철); 김기정; 박애자; Kwang-Ho Lee (이광호); 김경용; 김애진; KIM JAEHYUN (김재현); 노맹석; 다스제벡투멩

doi:10.11637/aba.2009.22.1.21

Comparison of SNP Occurred in Coding Regions of Mitochondrial DNA Analyzed from Korean and Mongolian

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2009, 22(1), pp.21~29
DOI : 10.11637/aba.2009.22.1.21
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

Kim Keun Cheol ¹, 김기정 ², 박애자 ², Kwang-Ho Lee ², 김경용 ², 김애진 ¹, KIM JAEHYUN ³, 노맹석 ⁴, 다스제벡투멩 ⁵

¹강원대학교
²중앙대학교
³동아대학교
⁴부경대학교
⁵몽골국립대학

Accredited

ABSTRACT

Even though mitochondrial DNA analysis is performed in the field of molecular genetics, differences of the results exist regarding which nucleotide positions are analyzed. In this study, we strategically analyzed to find ethnic specific SNP of coding regions of mitochondrial DNA of Korean and Mongolian. Mitochondrial DNA was analyzed with PCR amplification and sequencing with 112 blood samples of Korean and 92 blood samples of Mongolian. As a result, the mutation which commonly appears both in Korean and Mongolian population is 17 nucleotide positions, and the one that shown in the only Korean is 13 nucleotide positions, the one that shown in the only Mongolian 26 nucleotide positions. However, it was thought as individual variation as most mutations are shown in a sample. Among them, it appears as 9% substitution rate in 10397, 4850 nucleotide position of Korean, whereas 12.3% or 15% substitution rate in 5108, 9950 nucleotide positions of Mongolian, respectively. Beside, we observed high level of heteroplasmy in 3546, 3553 nucleotide positions. Therefore, we suggest that these regions might be novel genetic markers for dividing mitochondrial haplogroup of Korean and Mongolian population, but additional analysis needs on several nucleotide positions in huge samples as analyzing on restricted nucleotide positions using restricted DNA samples.

KEYWORDS

Mitochondrial DNA, SNP, Coding region, Korean, Mongolian

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Comparison of SNP Occurred in Coding Regions of Mitochondrial DNA Analyzed from Korean and Mongolian

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* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Comparison of SNP Occurred in Coding Regions of Mitochondrial DNA Analyzed from Korean and Mongolian

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