An Immune-compromised Method for Tooth Transplantation Using Adult Bone Marrow Stromal Cells and Embryonic Tooth Germ

권혁제; 박지희; 김은정; 이민정; 정한성; 조성원

doi:10.11637/aba.2011.24.4.217

An Immune-compromised Method for Tooth Transplantation Using Adult Bone Marrow Stromal Cells and Embryonic Tooth Germ

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2011, 24(4), pp.217~224
DOI : 10.11637/aba.2011.24.4.217
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy

권혁제 ¹, 박지희 ², 김은정 ², 이민정 ², 정한성 ², 조성원 ²

¹연세대학교
²연세대학교

Accredited

ABSTRACT

Tooth transplantation using autogenic adult teeth or embryonic tooth germs is the one of best treatments for replacement of missing teeth, but there are limitations in the accessibility. Isogenic or xenogenic tooth transplantation has been failed because of the immune rejection response occurring in the periodontal ligament of transplanted tooth. In this study, by utilizing the recombination between mouse embryonic tooth germ and mouse adult bone marrow stromal cells, we tried to replace the periodontal tissues such as periodontal ligament and alveolar bone with adult bone marrow stromal cells. At four weeks after the transplantation of the recombinant into a kidney,adult bone marrow-derived cells cells were observed in the periodontal ligament and alveolar bone. This result indicates that adult bone marrow stromal cells can participate in the formation of periodontal tissues. If these tooth and periodontal tissues are transplanted into host who donates adult bone marrow stromal cells, adult bone marrowderived cells will be regarded as host cells, and immune rejection response will not occur in these cells. Therefore,it is suggested that recombination between adult bone marrow stromal cells and embryonic tooth germ is a good candidate method using xenogenic tooth germ for replacement of missing teeth in human by replacing cells in periodontal tissues with human adult bone marrow stromal cells.

KEYWORDS

Tooth, Transplantation, Tooth germ, Bone marrow

Citation status

* References for papers published after 2023 are currently being built.

[journal] Akahane M / 2002 / Hydroxyapatite ceramics as a carrier of gene-transduced bone marrow cells / J Orthop Sci / 7 : 677~682

[journal] Bell P / 2005 / An optimized protocol for detection of E. coli beta-galactosidase in lung tissue following gene transfer / Histochem Cell Biol 124 : 77~85

[journal] 김재영 / 2003 / Lineage of non-cranial neural crest cell in the dental mesenchyme: using a lacZ reporter gene during early tooth development / JOURNAL OF ELECTRON MICROSCOPY / OXFORD UNIV PRESS 52 : 567~571

[journal] Coates PJ / 2001 / Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice / Oncogene / 20 : 7096~7097

[journal] Duailibi SE / 2008 / Bioengineered dental tissues grown in the rat jaw / J Dent Res / 87 : 745~750

[journal] Gronthos S / 2002 / Boyde A, DenBesten P, Robey PG, Shi S: Stem cell properties of human dental pulp stem cells / J Dent Res / 81 : 531~535

[journal] Hu B / 2006 / Tissue engineering of tooth crown, root, and periodontium / Tissue Eng 12 : 2069~2075

[journal] Ikeda E / 2009 / Fully functional bioengineered tooth replacement as an organ replacement therapy / Proc Natl Acad Sci USA / 106 : 13475~13480

[journal] Kopp HG / 2007 / Beta-galactosidase staining on bone marrow. The osteoclast pitfall / Histol Histopathol / 22 : 971~976

[journal] Huang AT / 2008 / Regeneration of dentin-pulp complex with cementum and periodontal ligament formation using dental bud cells in gelatinchondroitinhyaluronan tri-copolymer scaffold in swine / J Biomed Mater Res A 86 : 1062~1068

[journal] Mantesso A / 2009 / Dental stem cells for tooth regeneration and repair / Expert Opin Biol Ther 9 : 1143~1154

[journal] Nakao K / 2007 / The development of a bioengineered organ germ method / Nat Methods / 4 : 227~230

[journal] Ohazama A / 2004 / Stem-cellbased tissue engineering of murine teeth / J Dent Res / 83 : 518~522

[journal] Odgren PR / 2006 / False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice / Connect Tissue Res / 47 : 229~234

[journal] Owen M / 1988 / Marrow stromal cells / Journal of Cell Science 10 : 63~76

[journal] Robinson PJ / 1974 / Evidence of the alloimmunogenic potential of donor periodontal ligament / Am J Pathol 75 : 503~512

[journal] Rosenberg WS / 1992 / Authentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods / Res Mol Brain Res / 16 : 311~315

[journal] Seo BM / 2005 / Recovery of stem cells from cryopreserved periodontal ligament / J Dent Res 84 : 907~912

[journal] Song AM / 2007 / A study of enamel matrix proteins on differentiation of porcine bone marrow stromal cells into cementoblasts / Cell Prolif 40 : 381~396

[journal] Sonoyama W / 2008 / Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study / J Endod 34 : 166~171

[journal] Teitelbaum SL / 2000 / Bone resorption by osteoblasts / Science 289 : 1504~1508

[journal] Ten Cate AR / 1997 / The development of the periodontium-a largely ectomesenchymally derived unit / Periodontol 2000 13 : 9~19

[journal] Van der Weijden F / 2009 / lveolar bone dimensional changes of post-extraction sockets in humans: a systematic review / J Clin Periodontol 36 : 1048~1058

[journal] Yang Y / 2010 / Periodontal regeneration using engineered bone marrow mesenchymal stromal cells / Biomaterials 31 : 8574~8582

[journal] Young CS / 2002 / Tissue engineering of complex tooth structures on biodegradable polymer scaffolds / J Dent Res 81 : 695~700

[journal] Yen AH / 2006 / Regeneration of teeth using stem cell-based tissue engineering / Expert Opin Biol Ther 6 : 9~16

This paper was written with support from the National Research Foundation of Korea.

KJCKorea
Journal Central

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

An Immune-compromised Method for Tooth Transplantation Using Adult Bone Marrow Stromal Cells and Embryonic Tooth Germ

ABSTRACT

KEYWORDS

Citation status

* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

An Immune-compromised Method for Tooth Transplantation Using Adult Bone Marrow Stromal Cells and Embryonic Tooth Germ

ABSTRACT

KEYWORDS

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (0)

REFERENCES (26) * References for papers published after 2023 are currently being built.

Search PDF

Citation

* References for papers published after 2023 are currently being built.