Magnesium Hydride Attenuates Cognitive Impairment in a Rat Model of Vascular Dementia

Myeong Jin Lee (이명진); Ji Hye Lee; Do Kyung Kim; Nam Seob Lee (이남섭); Young-Gil Jeong; Ji Heun Jeong; Jong Ho Park; Yung Choon Yoo; Seung yun, Han (한승연)

doi:10.11637/aba.2020.33.3.125

Magnesium Hydride Attenuates Cognitive Impairment in a Rat Model of Vascular Dementia

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2020, 33(3), pp.125~134
DOI : 10.11637/aba.2020.33.3.125
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy
Received : March 2, 2020
Accepted : April 24, 2020
Published : September 29, 2020

Myeong Jin Lee ¹, Ji Hye Lee ², Do Kyung Kim ², Nam Seob Lee ¹, Young-Gil Jeong ¹, Ji Heun Jeong ², Jong Ho Park ³, Yung Choon Yoo ⁴, Seung yun, Han ¹

¹건양대학교
²Department of Anatomy, College of Medicine, Konyang University
³Department of Medicinal Materials, College of Medical Engineering, Konyang University
⁴건양대학교 의과대학

Accredited

ABSTRACT

Reactive oxygen species (ROS)-mediated oxidative stress plays a key role in the pathogenesis of central nervous system diseases, including vascular dementia (VaD). Thus, scientific attention has been given to the uptake of molecular hydrogen (H2), a powerful ROS scavenger that is abundant in nature, as a potential therapeutic candidate. Among the methods to supply H2, we selected an oral supplement of magnesium hydride (MgH2) and investigated its therapeutic role in cognitive impairment and hippocampal neuronal death associated with VaD. Sprague Dawley rats were randomly divided into 4 groups (n of each=8) and subjected to different conditions: SO, a group with vehicle and sham-operation; VEH, a group with a vehicle and 2VO/H (2 vessel occlusion and hypovolemia, used as a surgical model of VaD); MH-L, a group with low dose (5 mg/kg) of MgH2 and 2VO/H; and MH-H, a group with high dose (15 mg/kg) of MgH2 and 2VO/H. MgH2 or vehicle was administered via an intragastric route for 14 days before the operation. Subsequently, the memory performances of rats were tested using three behavior tests, i.e., Y-maze-, Barnes maze-, and passive avoidance tests (PAT). On postoperative day 8, the number of viable neurons in the hippocampal Cornu Ammonis (CA) 1 region was measured. The results of behavioral tests revealed that memory performance was significantly hampered in the VEH group when compared with the SO group; however, the extent of the impairment was markedly diminished in the MH-L and MH-H groups. While the number of pyramidal neurons in hippocampal CA1 was largely reduced in the VEH group when compared with the SO group, this reduction was significantly attenuated in the MH-L and MH-H groups. The effects of MgH2 were dose-dependent in PAT and histologic experiments. These results suggest that MgH2 supplementation can attenuate cognitive impairment and hippocampal neuronal death associated with VaD.

KEYWORDS

Magnesium hydride, Vascular dementia, 2VO/H, Hippocampal neuron

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This paper was written with support from the National Research Foundation of Korea.

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Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Magnesium Hydride Attenuates Cognitive Impairment in a Rat Model of Vascular Dementia

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* References for papers published after 2023 are currently being built.

Anatomy & Biological Anthropology 2023 KCI Impact Factor : 0.33

Magnesium Hydride Attenuates Cognitive Impairment in a Rat Model of Vascular Dementia

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