Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model

Chun Hua Piao; Yan Jing Fan; Thi Van Nguyen; Zhen Nan Yu; Hee Soon Shin (신희순); Chang Ho Song (송창호); Chai Ok Hee (채옥희)

doi:10.11637/aba.2021.34.2.45

Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model

Anatomy & Biological Anthropology
Abbr : Anat Biol Anthropol
2021, 34(2), pp.45~52
DOI : 10.11637/aba.2021.34.2.45
Publisher : 대한체질인류학회
Research Area : Medicine and Pharmacy > Anatomy
Received : June 1, 2021
Accepted : June 18, 2021
Published : June 30, 2021

Chun Hua Piao ¹, Yan Jing Fan ², Thi Van Nguyen ³, Zhen Nan Yu ³, Hee Soon Shin ⁴, Chang Ho Song ⁵, Chai Ok Hee ⁵

¹Yantai Yuhuangding Hospital
²Department of Anatomy, Jeonbuk National University
³Department of Anatomy, Jeonbuk National University Medical School
⁴한국식품연구원
⁵전북대학교

Accredited

ABSTRACT

Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.

KEYWORDS

Frutus amomi, Asthma, Th1/Th2 cytokine imbalance, OVA-specific IgE/IgG1/IgG2, NF-κB signaling

Journal Copyright Policy

No CCL information provided

Citation status

* References for papers published after 2025 are currently being built.

[journal] Lambrecht BN / 2015 / The immunology of asthma / Nat Immunol 16 : 45~56

[journal] You-Sun Kim / 2010 / IL-12-STAT4-IFN-γ axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model / Experimental and Molecular Medicine / 생화학분자생물학회 42(8) : 533~546

[journal] Woodruff PG / 2009 / T-helper type 2-driven inflammation defines major subphenotypes of asthma / Am J Respir Crit Care Med 180 : 388~395

[journal] Abdelmotelb AM / 2014 / Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma / Clin Exp Allergy 44 : 822~830

[journal] Punnonen J / 1994 / Role of interleukine-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells / Allergy 49 : 576~586

[journal] Cardamone C / 2016 / Mast cells as effector cells of innate immunity and regulators of adaptive immunity / Immunol Lett 178 : 10~14

[journal] Dahlin JS / 2015 / Mast cell progenitors : Origin, development and migration to tissues / Mol Immunol 63 : 9~17

[journal] Galli SJ / 2016 / The mast cell-IgE paradox : From homeostasis to anaphylaxis / Am J Pathol 186 : 212~224

[journal] Daugherty BL / 2004 / Histamine H4 antagonism : a therapy for chronic allergy / Br J Pharmacol 142 : 5~7

[journal] Guo DJ / 2008 / Antioxidative activities and the total phenolic contents of tonic Chinese medicinal herbs / Inflammopharmacology 16 : 201~207

[journal] Kim SH / 2007 / Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes / Food Chem Toxicol 45 : 2138~2144

[journal] Kwon KB / 2003 / Amomum xanthoides extract prevents cytokine-induced cell death of RINm5F cells through the inhibition of nitric oxide formation / Life Sci 73 : 181~191

[journal] 이윤경 / 2016 / Fructus Amomi Cardamomi Extract Inhibits Coxsackievirus-B3 Induced Myocarditis in a Murine Myocarditis Model / Journal of Microbiology and Biotechnology / 한국미생물·생명공학회 26(11) : 2012~2018

[journal] Choi HG / 2015 / Antiallergic inflammatory activities of compounds of Amomi Fructus / Nat Prod Commun 10 : 631~632

[journal] Bui TT / 2017 / Piper nigrum extract ameliorated allergic inflammation through inhibiting Th2/Th17 responses and mast cells activation / Cell Immunol 322 : 64~73

[journal] 송창호 / 2016 / Rosae Multiflorae Fructus Hot Water Extract Inhibits a Murine Allergic Asthma Via the Suppression of Th2 Cytokine Production and Histamine Release from Mast Cells / Journal of Medicinal Food / 한국식품영양과학회 19(9) : 853~859

[journal] Das J / 2001 / A critical role for NF-κB in GATA3 expression and Th2 differentiation in allergic airway inflammation / Nat Immunol 2 : 45~50

[journal] Galli SJ / 2008 / The development of allergic inflammation / Nature 454 : 445~454

[journal] Busse WW / 2003 / Mechanisms of asthma / J Allergy Clin Immunol 111 : S799~S804

[journal] Holgate S / 2005 / The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation / J Allergy Clin Immunol 115 : 459~465

[journal] Guo HW / 2014 / Mangiferin attenuates Th1/Th2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model / PLoS One 9 : e100394~

[journal] Li L / 1996 / Interleukin-12 stimulates B cell growth by inducing IFN-gamma / Cell Immunol 168 : 133~140

[journal] Cho JY / 2004 / Inhibition of airway remodeling in IL-5-deficient mice / J Clin Invest 113 : 551~560

[journal] Mican JA / 1992 / Passive cutaneous anaphylaxis in mouse skin is associated with local accumulation of interleukin-6 mRNA and immunoreactive interleukin-6 protein / J Allergy Clin Immunol 90 : 815~824

[journal] Roever AC / 2003 / Allergen-mediated modulation of CD23 expression is interferon-gamma and interleukin-10 dependent in allergic and non-allergic individuals / Clin Exp Allergy 33 : 1568~1575

[journal] Schulze-Luehrmann J / 2006 / Antigen-receptor signaling to nuclear factor κB / Immunity 25 : 701~715

[journal] El-Sherbeeny NA / 2016 / Tiron ameliorates oxidative stress and inflammation in a murine model of airway remodeling / Int Immunopharmacol 39 : 172~180

KJCKorea
Journal Central

Anatomy & Biological Anthropology 2025 KCI Impact Factor : 0.29

Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model

ABSTRACT

KEYWORDS

Journal Copyright Policy

Citation status

* References for papers published after 2025 are currently being built.

Anatomy & Biological Anthropology 2025 KCI Impact Factor : 0.29

Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model

ABSTRACT

KEYWORDS

Journal Copyright Policy

Statistics

Tools

Issue List

Citation status

KCI Citation Counts (0)

REFERENCES (27) * References for papers published after 2025 are currently being built.

Search PDF

Citation

* References for papers published after 2025 are currently being built.