@article{ART002729357},
author={Chun Hua Piao and Yan Jing Fan and Thi Van Nguyen and Zhen Nan Yu and Hee Soon Shin and Song Chang Ho and Chai Ok Hee},
title={Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2021},
volume={34},
number={2},
pages={45-52},
doi={10.11637/aba.2021.34.2.45}
TY - JOUR
AU - Chun Hua Piao
AU - Yan Jing Fan
AU - Thi Van Nguyen
AU - Zhen Nan Yu
AU - Hee Soon Shin
AU - Song Chang Ho
AU - Chai Ok Hee
TI - Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model
JO - Anatomy & Biological Anthropology
PY - 2021
VL - 34
IS - 2
PB - 대한체질인류학회
SP - 45
EP - 52
SN - 2671-5651
AB - Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.
KW - Frutus amomi;Asthma;Th1/Th2 cytokine imbalance;OVA-specific IgE/IgG1/IgG2;NF-κB signaling
DO - 10.11637/aba.2021.34.2.45
ER -
Chun Hua Piao, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Hee Soon Shin, Song Chang Ho and Chai Ok Hee. (2021). Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model. Anatomy & Biological Anthropology, 34(2), 45-52.
Chun Hua Piao, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Hee Soon Shin, Song Chang Ho and Chai Ok Hee. 2021, "Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model", Anatomy & Biological Anthropology, vol.34, no.2 pp.45-52. Available from: doi:10.11637/aba.2021.34.2.45
Chun Hua Piao, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Hee Soon Shin, Song Chang Ho, Chai Ok Hee "Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model" Anatomy & Biological Anthropology 34.2 pp.45-52 (2021) : 45.
Chun Hua Piao, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Hee Soon Shin, Song Chang Ho, Chai Ok Hee. Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model. 2021; 34(2), 45-52. Available from: doi:10.11637/aba.2021.34.2.45
Chun Hua Piao, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Hee Soon Shin, Song Chang Ho and Chai Ok Hee. "Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model" Anatomy & Biological Anthropology 34, no.2 (2021) : 45-52.doi: 10.11637/aba.2021.34.2.45
Chun Hua Piao; Yan Jing Fan; Thi Van Nguyen; Zhen Nan Yu; Hee Soon Shin; Song Chang Ho; Chai Ok Hee. Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model. Anatomy & Biological Anthropology, 34(2), 45-52. doi: 10.11637/aba.2021.34.2.45
Chun Hua Piao; Yan Jing Fan; Thi Van Nguyen; Zhen Nan Yu; Hee Soon Shin; Song Chang Ho; Chai Ok Hee. Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model. Anatomy & Biological Anthropology. 2021; 34(2) 45-52. doi: 10.11637/aba.2021.34.2.45
Chun Hua Piao, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Hee Soon Shin, Song Chang Ho, Chai Ok Hee. Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model. 2021; 34(2), 45-52. Available from: doi:10.11637/aba.2021.34.2.45
Chun Hua Piao, Yan Jing Fan, Thi Van Nguyen, Zhen Nan Yu, Hee Soon Shin, Song Chang Ho and Chai Ok Hee. "Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model" Anatomy & Biological Anthropology 34, no.2 (2021) : 45-52.doi: 10.11637/aba.2021.34.2.45
