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Response of Renal Intercalated Cells to Dietary Potassium Intake

  • Anatomy & Biological Anthropology
  • Abbr : Anat Biol Anthropol
  • 2023, 36(1), pp.1~7
  • DOI : 10.11637/aba.2023.36.1.1
  • Publisher : 대한체질인류학회
  • Research Area : Medicine and Pharmacy > Anatomy
  • Received : December 23, 2022
  • Accepted : January 11, 2023
  • Published : March 31, 2023

Su-Youn Lee 1 Ki Hwan Han 1

1이화여자대학교

Accredited

ABSTRACT

While ancient humans consumed enough potassium (K+), modern humans have insufficient K+ intake. The renal collecting duct plays an important role in regulating K+ homeostasis. There are at least three different types of cells in the collecting duct. The purpose of this study is to examine the effects of dietary K+ intake on collecting duct intercalated cells. C57BL/6 mice had free access to a control (1%), low (<0.01%), or high (5%) K+ diet for 1 week. Kidney tissue were processed for light microscopic immunohistochemistry and image analysis. Excessive dietary K+ intake or deficiency significantly changed blood K+ concentrations in mice. The size of type A intercalated cells increased by about 1.6 times in the low K+ group and decreased in the high K+ group. Conversely, the size of type B intercalated cells decreased in the low K+ group and increased in the high K+ group. The response of NANB cells to dietary K+ intake was generally like type B cells. These results demonstrated that renal intercalated cells vary greatly with dietary K+ intake. The structural changes in response to K+ imbalance may be closely related to cardiovascular and renal disorders in modern humans.

Citation status

* References for papers published after 2023 are currently being built.

This paper was written with support from the National Research Foundation of Korea.