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@article{ART002999983},
author={Yan Jing Fan and Juan Jin and Chun Hua Piao and Thi Van Nguyen and You-Suk Kim and Chai Ok Hee and Song Chang Ho},
title={Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2023},
volume={36},
number={3},
pages={127-138},
doi={10.11637/aba.2023.36.3.127}

TY - JOUR
AU - Yan Jing Fan
AU - Juan Jin
AU - Chun Hua Piao
AU - Thi Van Nguyen
AU - You-Suk Kim
AU - Chai Ok Hee
AU - Song Chang Ho
TI - Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway
JO - Anatomy & Biological Anthropology
PY - 2023
VL - 36
IS - 3
PB - 대한체질인류학회
SP - 127
EP - 138
SN - 2671-5651
AB - Allium hookeri (A. hookeri) has been used as a traditional medicine for many years in the Southeast Asian region. Multiple investigations have demonstrated its role in preventing of microbial infection, immune regulation, coronary thrombosis, and atherosclerosis has been demonstrated by several studies. Therefore, this study aims to investigate the suppressing effect of A. hookeri on the ovalbumin (OVA)-induced allergic rhinitis (AR) murine model. In this study, AR was induced in BALB/c mice by using OVA emulsified in aluminum on days 1, 8 and 15. Then, nasally challenged with OVA on days 22 to 28. On days 16 to 28, OVA-induced mice were treated either with A. hookeri (50, 100, 200 mg/kg) or Dexamethasone (Dex, 2.5 mg/kg) by oral gavage. On days 22 to 28, mice received either A. hookeri (50, 100, 200 mg/kg) or Dexamethasone (Dex, 2.5 mg/kg) an hour before the OVA challenge. The mice in the control group were not sensitized, treated, or tested. In this study, A. hookeri ameliorated nasal symptoms include rubbing and sneezing; reduced thickness of nasal mucosa; alleviated goblet cell hyperplasia and eosinophil infiltration in the nasal mucosa; decreased levels of OVA-specific IgE and OVA-specific IgG1 in serum; and suppressed Th2 (IL-4, IL-5, and IL-13) cytokines level in nasal lavage fluid (NALF). In addition, A. hookeri recovered the production of Th1 (IL-12 and IFN-γ) cytokines level in NALF, inhibited the inflammation through NF-κB pathway. Collectively, our results suggest that A. hookeri effectively protects against AR by regulating Th1/Th2 cytokines imbalance and NF-κB mechanisms. These observations suggest A. hookeri as a potential therapeutic option for AR.
KW - Allium hookeri;Allergic rhinitis;Th1 cytokines;Th2 cytokines;NF-κB
DO - 10.11637/aba.2023.36.3.127
ER -

Yan Jing Fan, Juan Jin, Chun Hua Piao, Thi Van Nguyen, You-Suk Kim, Chai Ok Hee and Song Chang Ho. (2023). Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway. Anatomy & Biological Anthropology, 36(3), 127-138.

Yan Jing Fan, Juan Jin, Chun Hua Piao, Thi Van Nguyen, You-Suk Kim, Chai Ok Hee and Song Chang Ho. 2023, "Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway", Anatomy & Biological Anthropology, vol.36, no.3 pp.127-138. Available from: doi:10.11637/aba.2023.36.3.127

Yan Jing Fan, Juan Jin, Chun Hua Piao, Thi Van Nguyen, You-Suk Kim, Chai Ok Hee, Song Chang Ho "Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway" Anatomy & Biological Anthropology 36.3 pp.127-138 (2023) : 127.

Yan Jing Fan, Juan Jin, Chun Hua Piao, Thi Van Nguyen, You-Suk Kim, Chai Ok Hee, Song Chang Ho. Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway. 2023; 36(3), 127-138. Available from: doi:10.11637/aba.2023.36.3.127

Yan Jing Fan, Juan Jin, Chun Hua Piao, Thi Van Nguyen, You-Suk Kim, Chai Ok Hee and Song Chang Ho. "Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway" Anatomy & Biological Anthropology 36, no.3 (2023) : 127-138.doi: 10.11637/aba.2023.36.3.127

Yan Jing Fan; Juan Jin; Chun Hua Piao; Thi Van Nguyen; You-Suk Kim; Chai Ok Hee; Song Chang Ho. Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway. Anatomy & Biological Anthropology, 36(3), 127-138. doi: 10.11637/aba.2023.36.3.127

Yan Jing Fan; Juan Jin; Chun Hua Piao; Thi Van Nguyen; You-Suk Kim; Chai Ok Hee; Song Chang Ho. Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway. Anatomy & Biological Anthropology. 2023; 36(3) 127-138. doi: 10.11637/aba.2023.36.3.127

Yan Jing Fan, Juan Jin, Chun Hua Piao, Thi Van Nguyen, You-Suk Kim, Chai Ok Hee, Song Chang Ho. Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway. 2023; 36(3), 127-138. Available from: doi:10.11637/aba.2023.36.3.127

Yan Jing Fan, Juan Jin, Chun Hua Piao, Thi Van Nguyen, You-Suk Kim, Chai Ok Hee and Song Chang Ho. "Allium hookeri Inhibits Inflammation in OVA-induced Allergic Rhinitis in Mice via NF-κB Pathway" Anatomy & Biological Anthropology 36, no.3 (2023) : 127-138.doi: 10.11637/aba.2023.36.3.127