Anatomy & Biological Anthropology 2025 KCI Impact Factor : 0.29
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pISSN : 2671-5651 / eISSN : 2671-566X
- https://journal.kci.go.kr/aba
KJCKorea
Journal Central
The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis
- Anatomy & Biological Anthropology
- Abbr : Anat Biol Anthropol
- 2025, 38(1), pp.9~19
- DOI : 10.11637/aba.2025.38.1.9
- Publisher : 대한체질인류학회
- Research Area : Medicine and Pharmacy > Anatomy
- Received : February 20, 2025
- Accepted : March 13, 2025
- Published : March 31, 2025
Jo Danbi
1,
Song Juhyun
1
1전남대학교 의과대학 해부학교실
Accredited
ABSTRACT
Intracranial atherosclerosis(ICAS) develops through complex interactions between multiple cell types, primarily cerebrovascular endothelial cells and neuroglia. The pathophysiology of ICAS involves progressive vascular wall remodeling, characterized by the accumulation of inflammatory cells, activated mesenchymal cells, oxidized lipids, and altered extracellular matrix components within the arterial intima, resulting in atherosclerotic plaque formation. Endothelial dysfunction represents a key initiating mechanism in atherogenesis. Endothelial reprogramming encompasses phenotypic plasticity and functional alterations of endothelial cells, including endothelial-to-mesenchymal transition (EndMT), transcriptional factors, cell signaling, growth factors, miRNAs. In the central nervous system, endothelial cell phenotype is intrinsically linked to blood-brain barrier (BBB) integrity and function. Therapeutic modulation of endothelial reprogramming presents a potential non-pharmacological cellular intervention strategy for ICAS. This review examines the mechanistic roles of endothelial cells in intracranial atherosclerosis and synthesizes current evidence regarding endothelial reprogramming in ICAS pathogenesis.
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This paper was written with support from the National Research Foundation of Korea.