@article{ART003186110},
author={Jo Danbi and Song Juhyun},
title={The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2025},
volume={38},
number={1},
pages={9-19},
doi={10.11637/aba.2025.38.1.9}
TY - JOUR
AU - Jo Danbi
AU - Song Juhyun
TI - The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis
JO - Anatomy & Biological Anthropology
PY - 2025
VL - 38
IS - 1
PB - 대한체질인류학회
SP - 9
EP - 19
SN - 2671-5651
AB - Intracranial atherosclerosis(ICAS) develops through complex interactions between multiple cell types, primarily cerebrovascular endothelial cells and neuroglia. The pathophysiology of ICAS involves progressive vascular wall remodeling, characterized by the accumulation of inflammatory cells, activated mesenchymal cells, oxidized lipids, and altered extracellular matrix components within the arterial intima, resulting in atherosclerotic plaque formation. Endothelial dysfunction represents a key initiating mechanism in atherogenesis. Endothelial reprogramming encompasses phenotypic plasticity and functional alterations of endothelial cells, including endothelial-to-mesenchymal transition (EndMT), transcriptional factors, cell signaling, growth factors, miRNAs. In the central nervous system, endothelial cell phenotype is intrinsically linked to blood-brain barrier (BBB) integrity and function. Therapeutic modulation of endothelial reprogramming presents a potential non-pharmacological cellular intervention strategy for ICAS. This review examines the mechanistic roles of endothelial cells in intracranial atherosclerosis and synthesizes current evidence regarding endothelial reprogramming in ICAS pathogenesis.
KW - Intracranial atherosclerosis (ICAS);Endothelial-to-mesenchymal cell transition (EndMT);Blood brain barrier(BBB);Endothelial reprogramming
DO - 10.11637/aba.2025.38.1.9
ER -
Jo Danbi and Song Juhyun. (2025). The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis. Anatomy & Biological Anthropology, 38(1), 9-19.
Jo Danbi and Song Juhyun. 2025, "The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis", Anatomy & Biological Anthropology, vol.38, no.1 pp.9-19. Available from: doi:10.11637/aba.2025.38.1.9
Jo Danbi, Song Juhyun "The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis" Anatomy & Biological Anthropology 38.1 pp.9-19 (2025) : 9.
Jo Danbi, Song Juhyun. The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis. 2025; 38(1), 9-19. Available from: doi:10.11637/aba.2025.38.1.9
Jo Danbi and Song Juhyun. "The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis" Anatomy & Biological Anthropology 38, no.1 (2025) : 9-19.doi: 10.11637/aba.2025.38.1.9
Jo Danbi; Song Juhyun. The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis. Anatomy & Biological Anthropology, 38(1), 9-19. doi: 10.11637/aba.2025.38.1.9
Jo Danbi; Song Juhyun. The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis. Anatomy & Biological Anthropology. 2025; 38(1) 9-19. doi: 10.11637/aba.2025.38.1.9
Jo Danbi, Song Juhyun. The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis. 2025; 38(1), 9-19. Available from: doi:10.11637/aba.2025.38.1.9
Jo Danbi and Song Juhyun. "The Importance of Endothelial Reprogramming in Intracranial Atherosclerosis" Anatomy & Biological Anthropology 38, no.1 (2025) : 9-19.doi: 10.11637/aba.2025.38.1.9
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