This study examined the structural relationships among stress of adult women, mindfulness, self-compassion, psychological well-being and psychological symptoms. 405 adult women completed a packet of questionnaires measuring the stressful life event, role stress, mindfulness, self-compassion, psychological well-being, and psychological symptom. Stress, mindfulness, self-compassion, and emotional well-being were defined theoretical latent variables. Hypothetical model for the paths and role among constructs of interest was presented drawing on previous theoretical background and analyses were performed using Structural Equation Modeling. The results show mindfulness and self-compassion mediate between stress and psychological well-being. Regarding psychological well-being, mediation model of mindfulness and self-compassion indicated reasonable model fit, but the path of self-compassion to psychological well-being is not significant. Meanwhile mediation model of mindfulness and self-compassion between stress and psychological symptom indicates reasonable fit, and all the paths turn out to be significant. These results indicated that self-compassion and mindfulness mediated the link between stress and psychological symptom. Implications for future research and practice are discussed.