This paper considers ethical aspects of human agency by comparing Sally McFague’s concept of ‘reflection’ and Karan Barad’s concept of ‘diffraction.’ Both McFague and Barad, arguing for neo-materialism which is monolitic, criticize the dualistic realism which has long been the epistemological and ontological foundation of the Christian theological tradition, especially the way of dividing soul and body and of meaning and matter. However, based on McFague’s understanding of divinity as “transcendent immanent” and of humanity in a dynamic relationship with the indwelling divinity(i.e. theosis and kenosis), this study distinguishes McFague’s ‘theological realism’ from Barad’s ‘agential realism’, which views that all beings are active agents entangled in “intra-action” of material world and thus the boundaries of existence are only temporary and contingent “phenomona.” In the sense of being a being who communicates with and reflects on the ‘divine spirit’, McFague’s ethical agent is ‘human,’ in particular ‘the first-world-humans’ who exclusively possess capital, knowledge, and advanced technology. Through reflective reason and spirituality, humans are able to carry out this ethical responsibility, even unfavorable to them, and respond to the ‘divine spirit’ that urges ‘universal values’ such as love, justice, and peace.