The purpose of this study is to investigate the effects of socioeconomic factors and digital media literacy on health information seeking behavior (HISB) through search engines and social networking services (SNS), and whether social support and life satisfaction as outcomes of HISB can be obtained through HISB using search engines and SNS. A nationwide online questionnaire was conducted on 1,000 male and female adults to obtain the data for this study. Results of this study demonstrated that women were more likely to seek health information using search engines than men were. The older the participants were, the more likely it was that they looked for health information using SNS as opposed to using a search engine. Access and creating dimension of digital media literacy had a positive impact on HISB via SNS, but understanding dimension of digital media literacy had a positive impact on HISB via search engines. HISB via SNS has more influence on information support and emotional support than HISB via search engines. HISB via SNS had a positive effect on life satisfaction, while HISB via search engines had a negative impact. Informational support and emotional support had a partially mediating effect on life satisfaction when participants used HISB via SNS. Based on these findings, the theoretical and practical implications are discussed.