This paper is a comparative study upon epistemology of East and West. The five Italic words in the summary are the key words of the paper. In classical western epistemology, knowing takes place within the relation between the knower and the known. In due such course the known acts as a cause as an individual unit. The knower is a mere receiver of the cause for the knowing. This is to say, according to Hume and Locke, an one-way situation. There is a sharp line between the knower and the known. This means that the known resides in different place providing a cause for knowing. This is the epistemological dichotomy of the West. Dewey criticizes the classical format of western epistemology insisting a different type of epistemology based upon continual interaction between the knower and the known. Dewey's idea can be put in two footings. First, there can be no absolutely independent and static individual in the world: whether the knower or the objects of knowing. Second, we, the subject of knowing are attached to the world, the object of knowing. It is quite interesting that Dewey's account on the world and knowing shares much common ground with that of Chuang Tzu. According to Chad Hansen, Chuang Tzu says of tao-t'ung-wei-i(道通爲一). This means that when 'I' chueh-te(覺得) Tao(道) through my innate kwang-ming-chih-hui(光明知慧) it is a recognition that 'I' and Tao(道) are not two but one. In Chinese philosophy, it is considered that epistemological dichotomy that draws a line between 'I' and the world may give us accuracy in knowing, but at the same time, it also renders us a division in 'I' and the world which is an inversive function for knowing. In Chinese philosophy, especially in Taoism, epistemological format includes a process of making the two(the knower and known) a comprehensive 'one'. Both Dewey's and Chuang Tzu's epistemology suggest the idea of interactionism or monism. This idea of dropping of dichotomy of knower and known can be called 'epistmological monism'. Wing Tsit Chan calls it "oneness" and Thomé H. Fang calls it "comprehensive harmony".