Purpose: This study was conducted to compare the characteristics of participants, depressive symptoms, marital intimacy, and health-related quality of life variables, as factors that affect groups with mild, moderate, and severe menopausal symptoms. Methods: Participants were 124 menopausal women between 40 and 64 years from D city, who were divided into three groups according to the severity of symptoms: mild, moderate, and severe with 22, 31, and 71 participants, respectively. Depressive symptoms, marital intimacy, and health-related quality of life variables(physical and mental health) were measured by a survey. Data were collected from November 1 to December 30, 2016 and analyzed using x2 test, one-way ANOVA, and multinomial logistic regression with SPSS/WIN 23.0. Results: Multinomial logistic regression results showed that the possibility of being categorized into the moderate group compared with the baseline group decreased by 13.38 times(OR=13.38, p<.001) as physical health decreased, 5.65 times(OR=5.65, p<.001) as mental health decreased, and 5.34 times(OR=5.34, p=.007) as depressive symptoms increased. This probability also increased by 1.23 times(OR=1.23, p=.032) as age increased. On the other hand, the probability of being classified under the severe group compared with the base group increased by 6.34 times(OR=6.34, p=.017) as depressive symptoms increased, 4.34 times(OR= 4.34, p=.023) as marital intimacy decreased, 5.65 times(OR=5.65, p=.008) as physical health decreased, 4.42 times(OR=4.42, p=.027) as mental health decreased, 4.37 times(OR=4.37, p=.030) as the age increased, and 17.31 times(OR=17.31, p<.001) as the postmenopausal period increased. Conclusion: Depressive symptoms, marital intimacy, and health-related quality of life were found to be significantly associated with the severity of menopausal symptoms. Therefore, it is necessary to develop nursing intervention strategies that can help create healthy lifestyle for menopausal women by emphasizing the improvement of health-related quality of life variables intimacy of the couple, and reduction of depressive symptoms in this population of women.