The purpose of this study is to select Asan-si, a medium-sized city with a continuously growing population, as a research area and to analyze changes in urban spatial structure. In order to achieve the purpose of the study, this study collects related data from population data, gross regional domestic product data, number of employees by industry, publicly notified individual land price data, and road network data, and then using a Moran’s I statistical analysis, vector analysis, and overlap analysis analyzed the concentration and distribution of functions, change of center, and patterns of urban spatial structures. As a result of the analysis of the research contents, it can be confirmed that the growth of the surrounding areas was more prominent than that of the existing central city area, and that the urban spatial structure was polycentered by the clustered branch type urban growth at the same time as the urban growth of the infill type. In addition, it has been revealed that Asan-si, which corresponds to the urban-rural integration city, has continued to have regional inequality between urban and rural areas. This study has significance in that it can be used as a reference for analyzing the correlation between urban growth and spatial change in the study of medium sized city with similar characteristics and scale.