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@article{ART001143896},
author={김민정 and 송수성 and 목우균 and 양준영 and 이건수 and 이영호},
title={Changes of Neuropathic Pain in nNOS Knock-out Mice},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2005},
volume={18},
number={4},
pages={303-312},
doi={10.11637/aba.2005.18.4.303}

TY - JOUR
AU - 김민정
AU - 송수성
AU - 목우균
AU - 양준영
AU - 이건수
AU - 이영호
TI - Changes of Neuropathic Pain in nNOS Knock-out Mice
JO - Anatomy & Biological Anthropology
PY - 2005
VL - 18
IS - 4
PB - 대한체질인류학회
SP - 303
EP - 312
SN - 2671-5651
AB - Changes in nitric oxide production in spinal cord or dorsal root ganglion have been known to contribute to allodynia after nerve injury. However, regulation of nNOS expression was also reported not to be responsible for the development and/or maintenance of neuropathic allodynia. The aim of this study was to elucidate role of nNOS expression in the sensory nervous system in neuropathic pain. Von Frey and acetone tests were performed in a model of peripheral neuropathy, ligation of 5th lumbar and 6th lumbar spinal nerves, in wild type and nNOS (-/-) mice. The effect of nNOS inhibitor was evaluated in neuropathic pain behavior in the mice. Mechanical allodynia was slightly reduced in nNOS (-/-) mice compared with wild type mice after peripheral neuropathy. nNOS inhibitor, L-NAME, reduced minimally mechanical allodynia, not cold allodynia, but gabapentin reduced remarkably neuropathic pain behavior (mechanical and cold allodynia) in both wild type and nNOS (-/-) mice. These results suggested that nNOS expression in the sensory nervous system may be partially associated with development and/or maintenance of mechanical allodynia in a mouse model of peripheral neuropathy.
KW - nNOS;Neuropathic pain;Allodynia;Nitric oxide
DO - 10.11637/aba.2005.18.4.303
ER -

김민정, 송수성, 목우균, 양준영, 이건수 and 이영호. (2005). Changes of Neuropathic Pain in nNOS Knock-out Mice. Anatomy & Biological Anthropology, 18(4), 303-312.

김민정, 송수성, 목우균, 양준영, 이건수 and 이영호. 2005, "Changes of Neuropathic Pain in nNOS Knock-out Mice", Anatomy & Biological Anthropology, vol.18, no.4 pp.303-312. Available from: doi:10.11637/aba.2005.18.4.303

김민정, 송수성, 목우균, 양준영, 이건수, 이영호 "Changes of Neuropathic Pain in nNOS Knock-out Mice" Anatomy & Biological Anthropology 18.4 pp.303-312 (2005) : 303.

김민정, 송수성, 목우균, 양준영, 이건수, 이영호. Changes of Neuropathic Pain in nNOS Knock-out Mice. 2005; 18(4), 303-312. Available from: doi:10.11637/aba.2005.18.4.303

김민정, 송수성, 목우균, 양준영, 이건수 and 이영호. "Changes of Neuropathic Pain in nNOS Knock-out Mice" Anatomy & Biological Anthropology 18, no.4 (2005) : 303-312.doi: 10.11637/aba.2005.18.4.303

김민정; 송수성; 목우균; 양준영; 이건수; 이영호. Changes of Neuropathic Pain in nNOS Knock-out Mice. Anatomy & Biological Anthropology, 18(4), 303-312. doi: 10.11637/aba.2005.18.4.303

김민정; 송수성; 목우균; 양준영; 이건수; 이영호. Changes of Neuropathic Pain in nNOS Knock-out Mice. Anatomy & Biological Anthropology. 2005; 18(4) 303-312. doi: 10.11637/aba.2005.18.4.303

김민정, 송수성, 목우균, 양준영, 이건수, 이영호. Changes of Neuropathic Pain in nNOS Knock-out Mice. 2005; 18(4), 303-312. Available from: doi:10.11637/aba.2005.18.4.303

김민정, 송수성, 목우균, 양준영, 이건수 and 이영호. "Changes of Neuropathic Pain in nNOS Knock-out Mice" Anatomy & Biological Anthropology 18, no.4 (2005) : 303-312.doi: 10.11637/aba.2005.18.4.303