@article{ART003218923},
author={Eun-Jeong Gwon and BAE ANNA and Park Jae-Hee and Lee, Jae-Ho},
title={EXO1 is a Potential Prognostic Biomarker in Lung Cancer},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2025},
volume={38},
number={2},
pages={123-128},
doi={10.11637/aba.2025.38.2.123}
TY - JOUR
AU - Eun-Jeong Gwon
AU - BAE ANNA
AU - Park Jae-Hee
AU - Lee, Jae-Ho
TI - EXO1 is a Potential Prognostic Biomarker in Lung Cancer
JO - Anatomy & Biological Anthropology
PY - 2025
VL - 38
IS - 2
PB - 대한체질인류학회
SP - 123
EP - 128
SN - 2671-5651
AB - Lung cancer is one of the most common malignancies worldwide and remains the leading cause of cancerrelated deaths. Exonuclease 1 (EXO1) is involved in several critical biological processes, including mismatch repair, double-strand break repair, and nucleotide excision repair. However, its precise role and association with lung cancer (LC) have not been fully elucidated. In this study, we investigated the clinicopathological and prognostic significance of EXO1 mRNA expression in 102 patients with LC. No statistically significant associations were observed between EXO1 expression and clinicopathological variables. However, survival analysis revealed that low EXO1 expression was significantly associated with poorer overall survival. Notably, among patients with squamous cell carcinoma (SCC), those with low EXO1 expression had significantly shorter overall survival compared to those with high expression levels. Our findings suggest that EXO1 may serve as a potential prognostic biomarker, particularly in SCC.
KW - EXO1;TCGA;Lung cancer;Biomarker
DO - 10.11637/aba.2025.38.2.123
ER -
Eun-Jeong Gwon, BAE ANNA, Park Jae-Hee and Lee, Jae-Ho. (2025). EXO1 is a Potential Prognostic Biomarker in Lung Cancer. Anatomy & Biological Anthropology, 38(2), 123-128.
Eun-Jeong Gwon, BAE ANNA, Park Jae-Hee and Lee, Jae-Ho. 2025, "EXO1 is a Potential Prognostic Biomarker in Lung Cancer", Anatomy & Biological Anthropology, vol.38, no.2 pp.123-128. Available from: doi:10.11637/aba.2025.38.2.123
Eun-Jeong Gwon, BAE ANNA, Park Jae-Hee, Lee, Jae-Ho "EXO1 is a Potential Prognostic Biomarker in Lung Cancer" Anatomy & Biological Anthropology 38.2 pp.123-128 (2025) : 123.
Eun-Jeong Gwon, BAE ANNA, Park Jae-Hee, Lee, Jae-Ho. EXO1 is a Potential Prognostic Biomarker in Lung Cancer. 2025; 38(2), 123-128. Available from: doi:10.11637/aba.2025.38.2.123
Eun-Jeong Gwon, BAE ANNA, Park Jae-Hee and Lee, Jae-Ho. "EXO1 is a Potential Prognostic Biomarker in Lung Cancer" Anatomy & Biological Anthropology 38, no.2 (2025) : 123-128.doi: 10.11637/aba.2025.38.2.123
Eun-Jeong Gwon; BAE ANNA; Park Jae-Hee; Lee, Jae-Ho. EXO1 is a Potential Prognostic Biomarker in Lung Cancer. Anatomy & Biological Anthropology, 38(2), 123-128. doi: 10.11637/aba.2025.38.2.123
Eun-Jeong Gwon; BAE ANNA; Park Jae-Hee; Lee, Jae-Ho. EXO1 is a Potential Prognostic Biomarker in Lung Cancer. Anatomy & Biological Anthropology. 2025; 38(2) 123-128. doi: 10.11637/aba.2025.38.2.123
Eun-Jeong Gwon, BAE ANNA, Park Jae-Hee, Lee, Jae-Ho. EXO1 is a Potential Prognostic Biomarker in Lung Cancer. 2025; 38(2), 123-128. Available from: doi:10.11637/aba.2025.38.2.123
Eun-Jeong Gwon, BAE ANNA, Park Jae-Hee and Lee, Jae-Ho. "EXO1 is a Potential Prognostic Biomarker in Lung Cancer" Anatomy & Biological Anthropology 38, no.2 (2025) : 123-128.doi: 10.11637/aba.2025.38.2.123
