@article{ART003218930},
author={Sang-Mok Yeo and Lee, june chai and Park, Jongho and Lee, Jae-Ho},
title={Clinical and Prognostic Values of REEP2 in Colorectal Cancer},
journal={Anatomy & Biological Anthropology},
issn={2671-5651},
year={2025},
volume={38},
number={2},
pages={129-134},
doi={10.11637/aba.2025.38.2.129}
TY - JOUR
AU - Sang-Mok Yeo
AU - Lee, june chai
AU - Park, Jongho
AU - Lee, Jae-Ho
TI - Clinical and Prognostic Values of REEP2 in Colorectal Cancer
JO - Anatomy & Biological Anthropology
PY - 2025
VL - 38
IS - 2
PB - 대한체질인류학회
SP - 129
EP - 134
SN - 2671-5651
AB - REEP2 (Receptor Expression-Enhancing Protein 2) has been implicated in various cellular processes, but its clinical relevance in colorectal cancer in colorectal cancer (CRC) remains unclear. This study aimed to evaluate the association between REEP2 expression and clinicopathologic features, molecular correlations, and patient prognosis in colon and rectal cancers using The Cancer Genome Atlas (TCGA) data. In rectal cancer, higher REEP2 expression has statistically significant relation with venous invasion, advanced pathologic stage, advanced M stage, and advanced N stage. In colon cancer, higher REEP2 expression has statistically significant relation with lymphatic invasion, venous invasion, advanced N stage, colon mucinous adenocarcinoma type, and anatomic neoplasm. Survival analysis showed that higher REEP2 expression was significantly associated with poorer overall survival in colon cancer (p=0.020), and showed a trend toward worse prognosis in rectal cancer (p=0.078). High REEP2 expression is associated with aggressive tumor characteristics and poor survival outcomes in colorectal cancer, particularly in colon cancer. To enhance our knowledge, further studies to demonstrate the molecular pathogenesis and clinical characteristics of REEP2 gene in colorectal cancer should be needed.
KW - REEP2;Colorectal cancer;TCGA;Cancer prognosis
DO - 10.11637/aba.2025.38.2.129
ER -
Sang-Mok Yeo, Lee, june chai, Park, Jongho and Lee, Jae-Ho. (2025). Clinical and Prognostic Values of REEP2 in Colorectal Cancer. Anatomy & Biological Anthropology, 38(2), 129-134.
Sang-Mok Yeo, Lee, june chai, Park, Jongho and Lee, Jae-Ho. 2025, "Clinical and Prognostic Values of REEP2 in Colorectal Cancer", Anatomy & Biological Anthropology, vol.38, no.2 pp.129-134. Available from: doi:10.11637/aba.2025.38.2.129
Sang-Mok Yeo, Lee, june chai, Park, Jongho, Lee, Jae-Ho "Clinical and Prognostic Values of REEP2 in Colorectal Cancer" Anatomy & Biological Anthropology 38.2 pp.129-134 (2025) : 129.
Sang-Mok Yeo, Lee, june chai, Park, Jongho, Lee, Jae-Ho. Clinical and Prognostic Values of REEP2 in Colorectal Cancer. 2025; 38(2), 129-134. Available from: doi:10.11637/aba.2025.38.2.129
Sang-Mok Yeo, Lee, june chai, Park, Jongho and Lee, Jae-Ho. "Clinical and Prognostic Values of REEP2 in Colorectal Cancer" Anatomy & Biological Anthropology 38, no.2 (2025) : 129-134.doi: 10.11637/aba.2025.38.2.129
Sang-Mok Yeo; Lee, june chai; Park, Jongho; Lee, Jae-Ho. Clinical and Prognostic Values of REEP2 in Colorectal Cancer. Anatomy & Biological Anthropology, 38(2), 129-134. doi: 10.11637/aba.2025.38.2.129
Sang-Mok Yeo; Lee, june chai; Park, Jongho; Lee, Jae-Ho. Clinical and Prognostic Values of REEP2 in Colorectal Cancer. Anatomy & Biological Anthropology. 2025; 38(2) 129-134. doi: 10.11637/aba.2025.38.2.129
Sang-Mok Yeo, Lee, june chai, Park, Jongho, Lee, Jae-Ho. Clinical and Prognostic Values of REEP2 in Colorectal Cancer. 2025; 38(2), 129-134. Available from: doi:10.11637/aba.2025.38.2.129
Sang-Mok Yeo, Lee, june chai, Park, Jongho and Lee, Jae-Ho. "Clinical and Prognostic Values of REEP2 in Colorectal Cancer" Anatomy & Biological Anthropology 38, no.2 (2025) : 129-134.doi: 10.11637/aba.2025.38.2.129
