The purpose of this study was to identify the predictive factors influencing spiritual resilience among Christians. To achieve this research goal, this study carefully examined (1) the relationships among spiritual resilience, spiritual well-being, God image, and self-esteem; (2) the overall model fit and explanatory power of factors affecting spiritual resilience; and (3) whether God image and self-esteem meaningfully mediate the relationship between spiritual well-being and spiritual resilience. The findings are as follows. First, significant positive correlations were clearly confirmed among spiritual resilience, spiritual well-being, God image, and self-esteem. Second, structural equation modeling indicated that spiritual well-being strongly predicted both God image and self-esteem, and that God image subsequently predicted spiritual resilience. Third, spiritual well-being predicted spiritual resilience indirectly through biblical God image, whereas the mediating effect of self-esteem in the relationship between spiritual well-being and spiritual resilience was not statistically significant. These results strongly suggest that Christians’ relational sense of well-being with God and their experience of personal life meaning positively influence the eventual formation of a biblical God image, which ultimately contributes to one of their essential key spiritual capacities, namely spiritual resilience. Based on these important findings, this study discusses the clinical and research implications for biblical counseling, carefully addresses its limitations, and proposes directions for significant future research.