Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking (생체내 정보 전달계 효소인 Phospholipase C 활성을 저해하는 Anguillosporal의 작용기전 )

Lee, Junwon (이준원); Bo Yeon Kim (김보연); AHN JONG SEOG (안종석)

Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking

Journal of Knowledge Information Technology and Systems
Abbr : JKITS
2010, 5(4), pp.19-26
Publisher : Korea Knowledge Information Technology Society
Research Area : Interdisciplinary Studies > Interdisciplinary Research
Published : August 31, 2010

Lee, Junwon ¹, Bo Yeon Kim ², AHN JONG SEOG ²

¹배재대학교
²한국생명공학연구원

Candidate

ABSTRACT

Anguillosporal dose-dependently inhibited phospholipase C (PLC)γ1 activity in A431 cells in response to epidermal growth factor (EGF). The compound also inhibited PLCβ1 activity in α-thrombin- stimulated CCL39 cells. In accordance with this, PLCγ1 and PLCβ1 activities were also decreased by anguillosporal in vitro. However, anguillosporal did not reduce the auto- phosphorylation of EGFR and the tyrosine phosphorylation of PLCγ1 in EGF-stimulated A431 cells. Also anguillosporal did not inhibit the tyrosine kinase activity of EGFR. From these results, it is suggested that anguillosporal is a specific inhibitor of phospholipase C.

KEYWORDS

Anguillosporal, phospholipase C, tyrosine phosphorylation, tyrosine kinase e

Citation status

* References for papers published after 2023 are currently being built.

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This paper was written with support from the National Research Foundation of Korea.

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