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Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking

  • Journal of Knowledge Information Technology and Systems
  • Abbr : JKITS
  • 2010, 5(4), pp.19-26
  • Publisher : Korea Knowledge Information Technology Society
  • Research Area : Interdisciplinary Studies > Interdisciplinary Research
  • Published : August 31, 2010

Lee, Junwon 1 Bo Yeon Kim 2 AHN JONG SEOG 2

1배재대학교
2한국생명공학연구원

Candidate

ABSTRACT

Anguillosporal dose-dependently inhibited phospholipase C (PLC)γ1 activity in A431 cells in response to epidermal growth factor (EGF). The compound also inhibited PLCβ1 activity in α-thrombin- stimulated CCL39 cells. In accordance with this, PLCγ1 and PLCβ1 activities were also decreased by anguillosporal in vitro. However, anguillosporal did not reduce the auto- phosphorylation of EGFR and the tyrosine phosphorylation of PLCγ1 in EGF-stimulated A431 cells. Also anguillosporal did not inhibit the tyrosine kinase activity of EGFR. From these results, it is suggested that anguillosporal is a specific inhibitor of phospholipase C.

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This paper was written with support from the National Research Foundation of Korea.