@article{ART001478865},
author={Lee, Junwon and Bo Yeon Kim and AHN JONG SEOG},
title={Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking},
journal={Journal of Knowledge Information Technology and Systems},
issn={1975-7700},
year={2010},
volume={5},
number={4},
pages={19-26}
TY - JOUR
AU - Lee, Junwon
AU - Bo Yeon Kim
AU - AHN JONG SEOG
TI - Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking
JO - Journal of Knowledge Information Technology and Systems
PY - 2010
VL - 5
IS - 4
PB - Korea Knowledge Information Technology Society
SP - 19
EP - 26
SN - 1975-7700
AB - Anguillosporal dose-dependently inhibited phospholipase C (PLC)γ1 activity in A431 cells in response to epidermal growth factor (EGF). The compound also inhibited PLCβ1 activity in α-thrombin- stimulated CCL39 cells. In accordance with this, PLCγ1 and PLCβ1 activities were also decreased by anguillosporal in vitro. However, anguillosporal did not reduce the auto- phosphorylation of EGFR and the tyrosine phosphorylation of PLCγ1 in EGF-stimulated A431 cells. Also anguillosporal did not inhibit the tyrosine kinase activity of EGFR. From these results, it is suggested that anguillosporal is a specific inhibitor of phospholipase C.
KW - Anguillosporal;phospholipase C;tyrosine phosphorylation;tyrosine kinase e
DO -
UR -
ER -
Lee, Junwon, Bo Yeon Kim and AHN JONG SEOG. (2010). Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking. Journal of Knowledge Information Technology and Systems, 5(4), 19-26.
Lee, Junwon, Bo Yeon Kim and AHN JONG SEOG. 2010, "Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking", Journal of Knowledge Information Technology and Systems, vol.5, no.4 pp.19-26.
Lee, Junwon, Bo Yeon Kim, AHN JONG SEOG "Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking" Journal of Knowledge Information Technology and Systems 5.4 pp.19-26 (2010) : 19.
Lee, Junwon, Bo Yeon Kim, AHN JONG SEOG. Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking. 2010; 5(4), 19-26.
Lee, Junwon, Bo Yeon Kim and AHN JONG SEOG. "Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking" Journal of Knowledge Information Technology and Systems 5, no.4 (2010) : 19-26.
Lee, Junwon; Bo Yeon Kim; AHN JONG SEOG. Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking. Journal of Knowledge Information Technology and Systems, 5(4), 19-26.
Lee, Junwon; Bo Yeon Kim; AHN JONG SEOG. Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking. Journal of Knowledge Information Technology and Systems. 2010; 5(4) 19-26.
Lee, Junwon, Bo Yeon Kim, AHN JONG SEOG. Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking. 2010; 5(4), 19-26.
Lee, Junwon, Bo Yeon Kim and AHN JONG SEOG. "Mechanism of Anguillosporal Inhibitory Activity for Phospholipase C as the Signal Transducer in the Biological Networking" Journal of Knowledge Information Technology and Systems 5, no.4 (2010) : 19-26.