RIP function on osteoclastogenesis

Lee, Junwon (이준원)

RIP function on osteoclastogenesis

Journal of Knowledge Information Technology and Systems
Abbr : JKITS
2015, 10(5), pp.567-574
Publisher : Korea Knowledge Information Technology Society
Research Area : Interdisciplinary Studies > Interdisciplinary Research
Published : October 31, 2015

Lee, Junwon ¹

¹배재대학교

Accredited

ABSTRACT

Bone is continuously remodeled by osteoblasts and osteoclasts. Proper balance between bone matrix formation by osteoblasts and resorption by osteoclasts is essential for proper bone metabolism and these processes are tightly regulated by various hormones and cytokines in local microenvironments. Osteoclasts are multinucleated cells that form only in bone and specialize in the resorption of calcified matrix. Osteoclasts were derive from hematopoietic cells in the bone marrow and stimulated by receptor activator of nuclear factor NF-κB ligand (TRANCE, RANKL). RIP is known as a potent therapeutic agent with anti-inflammatory by activation of T cell potential. However, the regulatory effects of RIP on osteoclast differentiation are unclear. In this study, We examined the effects of RIP on osteoclast differentiation with respect to bone resorption. RIP negatively regulates TRANCE-induced osteoclast differentiation. Expression levels of RIP are significantly reduced by TRANCE during osteoclastogenesis. Overexpression of RIP in bone marrow-derived monocyte/macrophage lineage cells (BMMs) inhibits the formation of TRAP multinuclear osteoclasts. Furthermore, overexpression of RIP in BMMs attenuates the gene induction of nuclear factor of activated T cells (NFAT) c1 and osteoclast-associated receptor (OSCAR) during TRANCE-mediated osteoclastogenesis. Taken together, our results suggest that RIP can act as an important modulator of TRANCE-mediated osteoclastogenesis.

KEYWORDS

Osteoporosis, Osteoclasts, Inhibitory activities, RIP, TRAP

Citation status

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This paper was written with support from the National Research Foundation of Korea.

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