@article{ART001748567},
author={SangChul Jeong and Lee,Eun-Sook and Lee, Junwon and Kim， Jin Hee},
title={Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity},
journal={Journal of Knowledge Information Technology and Systems},
issn={1975-7700},
year={2013},
volume={8},
number={1},
pages={63-73}
TY - JOUR
AU - SangChul Jeong
AU - Lee,Eun-Sook
AU - Lee, Junwon
AU - Kim， Jin Hee
TI - Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity
JO - Journal of Knowledge Information Technology and Systems
PY - 2013
VL - 8
IS - 1
PB - Korea Knowledge Information Technology Society
SP - 63
EP - 73
SN - 1975-7700
AB - For the development of the anti-obesity compounds from natural sources, the tests was carried out with Korean Traditional Medicinal Plants (KTMP) by inhibitory activity of pancreatic lipase enzyme assay with porcine pancreatic lipase (type VI-S, porcine pancreas from Sigma). Among the 131 Korean traditional medicinal plants, 33 KTMP extracts exhibited a significant inhibitory activity against pancreatic lipase in in vitro study. The methanol extracts of four KTMP namely, Areca catechu, Rheum undulatum, Orostachys japonicus, and Cibotium barometz, exhibited strong in vitro anti-lipase activity above 60% at the 100㎍/ml concentration. Particularly, the methanol extract of Rheum undulatum showed highest pancreatic lipase inhibitory activity as 72.0% followed by Cibotium barometz (70.2%) which were higher than orlistat at the 0.495㎍/ml concentration as positive control. The other 6 kinds of KTMP (Curcuma zedoaria, Rubia akane, Sanguisorba officinalis, Curcuma longa Linn, Artemisia scoparia and Omphalia lapidescens) also showed the over 40% of pancreatic lipase inhibitory activity. To the best of our knowledge, many KTMP have been screened for their pancreatic lipase inhibitory activity in the previously report. However, it’s too small study compared to the entire KTMP. Therefore, our results provide the more valuable information for studied the anti-obesity compounds from Korean traditional medicinal plants.
KW - Pancreatic lipase;Obesity;Lipase inhibitor;Korean Traditional Medicinal Plants (KTMP)
DO -
UR -
ER -
SangChul Jeong, Lee,Eun-Sook, Lee, Junwon and Kim， Jin Hee. (2013). Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity. Journal of Knowledge Information Technology and Systems, 8(1), 63-73.
SangChul Jeong, Lee,Eun-Sook, Lee, Junwon and Kim， Jin Hee. 2013, "Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity", Journal of Knowledge Information Technology and Systems, vol.8, no.1 pp.63-73.
SangChul Jeong, Lee,Eun-Sook, Lee, Junwon, Kim， Jin Hee "Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity" Journal of Knowledge Information Technology and Systems 8.1 pp.63-73 (2013) : 63.
SangChul Jeong, Lee,Eun-Sook, Lee, Junwon, Kim， Jin Hee. Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity. 2013; 8(1), 63-73.
SangChul Jeong, Lee,Eun-Sook, Lee, Junwon and Kim， Jin Hee. "Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity" Journal of Knowledge Information Technology and Systems 8, no.1 (2013) : 63-73.
SangChul Jeong; Lee,Eun-Sook; Lee, Junwon; Kim， Jin Hee. Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity. Journal of Knowledge Information Technology and Systems, 8(1), 63-73.
SangChul Jeong; Lee,Eun-Sook; Lee, Junwon; Kim， Jin Hee. Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity. Journal of Knowledge Information Technology and Systems. 2013; 8(1) 63-73.
SangChul Jeong, Lee,Eun-Sook, Lee, Junwon, Kim， Jin Hee. Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity. 2013; 8(1), 63-73.
SangChul Jeong, Lee,Eun-Sook, Lee, Junwon and Kim， Jin Hee. "Study of Medicinal Plants for Regulation of Pancreatic Lipase Activity" Journal of Knowledge Information Technology and Systems 8, no.1 (2013) : 63-73.
