Purpose: This study aimed to investigate the influence of stress, anxiety, and depression on the quality of sleep in patients with chest pain. Methods: A descriptive correlation design was used. Eighty-eight patients with chest pain who were admitted to the cardiology department at the P National University Hospital to undergo coronary angiography were recruited as participants. The data were collected using the Visual Analog Scale (VAS), the Canadian Cardiovascular Society Classification (CCSC), the Perceived Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI), the Beck Depression Inventory (BDI), and the Pittsburgh Sleep Quality Index (PSQI). The date were analyzed using t-test, ANOVA, Pearson's correlation coefficient, and hierarchical multiple regression using the SPSS 23.0 program. Results: There were significant correlations between quality of sleep and total cholesterol (r=.24, p=.029), and low-density cholesterol (r=.26, p=.020). There were significant positive correlations between quality of sleep and stress (r=.40, p<.001), anxiety (r=.29, p=.007), and depression (r=.38, p<.001). The factor affecting the quality of sleep was stress (β=.38, p=.011), which explained 22.6% of the variance. The quality of sleep was significantly worse when reported stress levels was higher. Conclusion: When developing a sleep management program for patients with chest pain, it is necessary to consider the stress levels of the patient.