The purpose of this study is to investigate the relationship among family function, self-esteem, and powerlessness for Korean-Chinese college students. The subjects were 130 Korean-Chinese college students aged 19 to 26 years (M±SD=21.4±1.47) who were living in Yanji, China. Data were collected from March to April, 2015. To measure the level of family function, self-esteem, and powerlessness, APGAR Family function scale, a Rosenberg Self-esteem scale, and a powerlessness scale were used to Korean-Chinese college students. Economic status (t=2.42, p=.017), satisfaction with allowances (F=6.70, p=.002), health status (F=5.03, p=.008), whether or not students were separated from their father (t=3.23, p=.002) and their mother (t=2.48, p=.015) at the time of data collection, and drinking status (t=-2.05, p=.043) were significant variables in the family function. Self-esteem was significantly different by school satisfaction (F=3.62, p=.030) and reasons for separation from father (t=-2.19, p=.032). Powerlessness was significantly different by age (F=4.53, p=.013 ), grade (F=6.30, p=.001), school satisfaction (F=3.10, p=.049), health status (F=5.73, p=.004), and whether or not students were separated from their mother (t=-2.88, p=.005). The results shows that family function was associated with self-esteem and low powerlessness. The predictors of self-esteem were family function and school satisfaction. Good health, separation from the mother, and family function affected in powerlessness. Therefore, culturally appropriate program interventions are needed in order to increase family function for Korean-Chinese college students separated from a parent.