In this experiment, we evaluated the anti-microbial, anti-oxidant and anti-platelet activities using 70% ethanol extract of natual products, Natural products (Lycium chinense, Aralia cordata, Achyranthes japonica, Mentha canadensis, Eriobotrya japonica, Belamcanda chinensis, Phlomis umbrosa, Lespedeza cuneata, Kalopanax septemlobus, Nelumbo nucifera) were extracted with 70% ethanol, freeze-dried, and used in the experiment. All natural products exhibited antibacterial activities, and Aralia cordata, Achyranthes japonica, Eriobotrya japonica, Belamcanda chinensis, and Nelumbo nucifera showed strong antimicrobial effect. Next, we investigated the antioxidant activity, polyphenol and flavonoid content and antiplatelet activity of the natural products. As a result, Aralia cordata, Achyranthes japonica, Eriobotrya japonica, Belamcanda chinensis, and Nelumbo nucifera showed antiplatelet effect and Ca2+ inhibitory activity. Therefore, it was confirmed that the five natural product extracts have a potential to prevent antibacterial, antioxidant, and antiplatelet-related diseases, and it is suggested that they can be developed as materials for functional foods and pharmaceuticals in the future.